Pasquier F, Petit H
Department of Neurology, University Hospital, Lille, France.
Eur Neurol. 1997;38(1):1-6. doi: 10.1159/000112894.
Frontotemporal dementia (FTD) is the second most frequent degenerative cause of dementia. Although described for more than a century, it remains often misdiagnosed, mistaken for Alzheimer's disease or psychiatric disorders, which is prejudicial to care and research. It is a clinical syndrome corresponding to at least three histological entities: (1) Pick's disease, (2) non-specific frontotemporal degeneration, (6 times more frequent), and (3) frontal lobe abnormalities associated with motor neurone disease. It never corresponds to Alzheimer pathology. It must be suspected in patients with behavioural dyscontrol predating memory impairment, without spatial disorientation and normal EEG.
额颞叶痴呆（FTD）是第二常见的痴呆退行性病因。尽管已被描述了一个多世纪，但它仍常常被误诊，被误认为是阿尔茨海默病或精神疾病，这对护理和研究都不利。它是一种临床综合征，至少对应三种组织学类型：（1）皮克病，（2）非特异性额颞叶变性（频率高6倍），以及（3）与运动神经元病相关的额叶异常。它从不对应阿尔茨海默病的病理特征。对于行为失控早于记忆损害、无空间定向障碍且脑电图正常的患者，必须怀疑患有此病。
