Patel H I
Berlex Laboratories, Inc. Wayne, New Jersey 07470-7358, USA.
J Biopharm Stat. 1997 Jul;7(3):369-81. doi: 10.1080/10543409708835194.
This paper deals with a method of analyzing incomplete data, forming a monotone pattern, from a within-subject design with baseline measurements. An assumption of multivariate normality with antedependence structure is made for both the baseline measurements and the response measurements. Adjusted means for the period-by-sequence cells and their dispersion matrix are obtained. Large sample tests are proposed for testing various hypotheses. A numerical example is given to illustrate the methodology.
本文探讨了一种用于分析来自具有基线测量的受试者内设计的不完整数据并形成单调模式的方法。对基线测量和响应测量均做出了具有反相依结构的多元正态性假设。得到了按周期 - 序列单元格的调整均值及其离散矩阵。提出了用于检验各种假设的大样本检验方法。给出了一个数值示例以说明该方法。
