Ross R
Department of Pathology, University of Washington School of Medicine, Seattle 98195-7470, USA.
Atherosclerosis. 1997 Jun;131 Suppl:S3-4. doi: 10.1016/s0021-9150(97)06114-5.
The lesions of atherosclerosis represent a protective, inflammatory-fibroproliferative response against the different agents which can cause the disease. With a chronic insult, the response may become excessive and thus constitute part of the disease process. The excessive response may be reversed, given sufficient opportunity for modification of the injurious factors. Approaches to modifying specific cellular interactions, growth-regulatory molecules or intracellular signaling molecules may afford opportunities for lesion prevention or regression. For further reading see [1,2].
动脉粥样硬化病变是针对可引发该疾病的不同因素的一种保护性炎症纤维增生反应。在慢性损伤的情况下，这种反应可能会过度，从而构成疾病进程的一部分。如果有足够的机会改变损伤因素，过度反应可能会逆转。改变特定细胞相互作用、生长调节分子或细胞内信号分子的方法可能为病变的预防或消退提供机会。如需进一步阅读，请参阅[1,2]。
