Caddy K W, Vozeh F
Department of Physiology, University College London, UK.
Eur J Pharmacol. 1997 Jul 9;330(2-3):139-42. doi: 10.1016/s0014-2999(97)01030-3.
Lurcher mutant and wild-type mice were given intraperitoneal injections of 3-acetylpyridine to look at the toxic effects of this drug on the inferior olivary neurons. Intraperitoneal administration of 3-acetylpyridine is characterized by the different sensitivity of inferior olivary neurons in Lurcher mutant and wild-type mice. Lurcher mutants suffered a destruction of these neurons while wild-type mice were unaffected. The results show that there is a different effect of 3-acetylpyridine between genetic mutations and wild-type mice on the same inbred strain of mice. The different affinity of 3-acetylpyridine for the inferior olivary neurons of this mutant is briefly discussed.
给蹒跚突变型和野生型小鼠腹腔注射3-乙酰吡啶，以观察该药物对下橄榄核神经元的毒性作用。腹腔注射3-乙酰吡啶的特点是，蹒跚突变型和野生型小鼠的下橄榄核神经元敏感性不同。蹒跚突变型小鼠的这些神经元遭到破坏，而野生型小鼠未受影响。结果表明，在同一近交系小鼠中，基因突变型和野生型小鼠对3-乙酰吡啶的反应不同。文中简要讨论了3-乙酰吡啶对该突变体下橄榄核神经元的不同亲和力。
