在神经和浦肯野细胞变性突变体中，小脑一氧化氮合酶活性降低，但在攀缘纤维损伤的小鼠中未降低。

Cerebellar nitric oxide synthase activity is reduced in nervous and Purkinje cell degeneration mutants but not in climbing fiber-lesioned mice.

作者信息

Ikeda M, Morita I, Murota S, Sekiguchi F, Yuasa T, Miyatake T

机构信息

Department of Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Japan.

出版信息

Neurosci Lett. 1993 Jun 11;155(2):148-50. doi: 10.1016/0304-3940(93)90694-g.

DOI:10.1016/0304-3940(93)90694-g

PMID:7690917

Abstract

We measured nitric oxide synthase activity in nervous, Purkinje cell degeneration mutant mice and 3-acetylpyridine-treated mice to determine the cellular localization of nitric oxide synthase in the cerebellum. Nitric oxide synthase activity per cerebellum was reduced to less than 50% of that of controls in nervous and Purkinje cell degeneration mutants, while in 3-acetylpyridine-treated mice there was no reduction.

摘要

我们测定了神经型、浦肯野细胞变性突变小鼠和3-乙酰吡啶处理小鼠的一氧化氮合酶活性，以确定小脑一氧化氮合酶的细胞定位。在神经型和浦肯野细胞变性突变小鼠中，每小脑的一氧化氮合酶活性降至对照组的50%以下，而在3-乙酰吡啶处理的小鼠中则没有降低。