Chang T C, Huang K M, Hsiao Y L, Tzeng S S, Kao S C
Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Republic of China.
Acta Ophthalmol Scand. 1997 Jun;75(3):301-4. doi: 10.1111/j.1600-0420.1997.tb00779.x.
To elucidate the relationships of orbital computed tomographic findings and activity scores to the prognosis of corticosteroid therapy in patients with Graves' ophthalmopathy, 22 cases were treated with corticosteroid. Orbital computed tomographic was performed before treatment and the maximal muscle areas of rectus muscle bellies were calculated from the coronal images. Activity scores were calculated according to the recommendations of an international ad hoc committee. The clinical severity of the eye disease was based on the NOSPECS classification. Observation of the effectiveness of treatment at 6 months allowed patients to be classified into good responders or poor responders. Twelve of 22 patients (54.5%) belonged to the good responders. The total muscle areas were less in good responders. Although the total muscle areas were significantly correlated with the activity scores, no difference in the activity scores was noted between these two groups. We concluded that although activity score seems to be a predictor of initial responsiveness to anti-inflammatory drugs, the maximal muscle area is a prognostic factor of corticosteroid therapy in patients with Graves' ophthalmopathy.
为阐明眼眶计算机断层扫描结果及活动评分与格雷夫斯眼病患者皮质类固醇治疗预后的关系，对22例患者进行了皮质类固醇治疗。治疗前进行眼眶计算机断层扫描，并从冠状位图像计算直肌肌腹的最大面积。根据一个国际特设委员会的建议计算活动评分。眼病的临床严重程度基于NOSPECS分类。观察6个月时的治疗效果，将患者分为反应良好者或反应不佳者。22例患者中有12例（54.5%）属于反应良好者。反应良好者的总肌肉面积较小。虽然总肌肉面积与活动评分显著相关，但两组之间的活动评分没有差异。我们得出结论，虽然活动评分似乎是对抗炎药物初始反应性的一个预测指标，但最大肌肉面积是格雷夫斯眼病患者皮质类固醇治疗的一个预后因素。
