Iams S G, Wexler B C
J Lab Clin Med. 1977 Dec;90(6):997-1003.
Young normotensive, male and female rats which develop hypertension spontaneously as they mature were gonadectomized when they were 30 days old. With time, intact controls and sham-operated controls showed a progressive increase in their blood pressure, attaining systolic pressure levels of 180 to 200 mm Hg when they were 120 days old. During this same period, the gonadectomized animals manifested a slight increase in blood pressure without becoming hypertensive. In keeping with their normotensive levels, the gonadectomized rats did not develop any cardiac or renal enlargement. Orchiectomy was associated with retardation of growth, an increase in the ratio of adrenal weight/body weight, concomitant with increased circulating levels of DOC in males vs. reduced DOC levels in females. There was no change in aldosterone levels in either sex. Cmpd. B levels were increased in the gonadectomized males and were slightly reduced in the gonadectomized females. The changes in Cmpd. B, DOC, and aldosterone in these gonadectomized animals cannot account for the inhibition of the spontaneously developing hypertension.
年轻的血压正常的雄性和雌性大鼠在成熟过程中会自发患上高血压，它们在30日龄时接受了性腺切除手术。随着时间的推移，完整对照组和假手术对照组的血压逐渐升高，在120日龄时收缩压达到180至200毫米汞柱。在同一时期，性腺切除的动物血压略有升高，但并未发展为高血压。与它们的正常血压水平一致，性腺切除的大鼠没有出现任何心脏或肾脏增大。睾丸切除与生长迟缓、肾上腺重量与体重之比增加有关，同时雄性动物体内循环的脱氧皮质酮（DOC）水平升高，而雌性动物体内DOC水平降低。两性的醛固酮水平均无变化。化合物B的水平在性腺切除的雄性动物中升高，在性腺切除的雌性动物中略有降低。这些性腺切除动物中化合物B、DOC和醛固酮的变化无法解释对自发性高血压发展的抑制作用。
