X连锁高IgM综合征中抗原诱导的淋巴细胞增殖缺陷。
Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome.
作者信息
Ameratunga R, Lederman H M, Sullivan K E, Ochs H D, Seyama K, French J K, Prestidge R, Marbrook J, Fanslow W C, Winkelstein J A
机构信息
Department of Molecular Medicine, University of Auckland, New Zealand.
出版信息
J Pediatr. 1997 Jul;131(1 Pt 1):147-50. doi: 10.1016/s0022-3476(97)70139-2.
We examined T-cell proliferation in five patients with X-linked hyper-IgM syndrome (XHIM), using a panel of antigens and lectins. All patients had impaired antigen-induced proliferation, whereas their lectin responses were normal. Thus, in addition to severely depressed antibody responses, patients with XHIM have a defect in antigen-specific T-cell proliferation, which may explain their susceptibility to pathogens such as Pneumocystis carinii.
我们使用一组抗原和凝集素检测了5例X连锁高IgM综合征（XHIM）患者的T细胞增殖情况。所有患者的抗原诱导增殖均受损，而他们对凝集素的反应正常。因此，除了严重降低的抗体反应外，XHIM患者还存在抗原特异性T细胞增殖缺陷，这可能解释了他们对卡氏肺孢子虫等病原体的易感性。
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