Kyndt X, Hebbar M, Queyrel V, Hachulla E, Hatron P Y, Devulder B
Service de médecine interne A, hôpital Claude-Huriez 1, Lille, France.
Rev Med Interne. 1997 Jul;18(7):528-32. doi: 10.1016/s0248-8663(97)80804-1.
Several studies have suggested an increased risk of cancer in patients with systemic sclerosis, but the potential risk factors for these cancers remain unknown. The aim of this study was to identify, among patients with systemic sclerosis, factors associated with the development of cancer, with attention to clinical (age, sex, cutaneous sclerosis), immunological (antinuclear antibodies, anticentromere antibodies, anti-Scl-70 antibodies) and histological (pulmonary fibrosis) features. We retrospectively studied 123 patients with systemic sclerosis. The median follow-up period was 4 years. Fourteen cases of cancer (11.3%) were found (lung n = 3, breast n = 2, ovarian n = 2, skin n = 1, thyroid n = 1, rectum n = 1, uterine cervix n = 1, larynx n = 1, pancreas n = 1, myelodysplasia n = 1). The characteristics of systemic sclerosis were similar in patients with and patients without cancer. Yet, the three cases of lung cancers occurred in association with CREST syndromes and anticentromere antibodies.
多项研究表明，系统性硬化症患者患癌风险增加，但这些癌症的潜在风险因素仍不明确。本研究的目的是在系统性硬化症患者中确定与癌症发生相关的因素，重点关注临床（年龄、性别、皮肤硬化）、免疫（抗核抗体、抗着丝点抗体、抗Scl-70抗体）和组织学（肺纤维化）特征。我们对123例系统性硬化症患者进行了回顾性研究。中位随访期为4年。发现14例癌症（11.3%）（肺癌3例、乳腺癌2例、卵巢癌2例、皮肤癌1例、甲状腺癌1例、直肠癌1例、子宫颈癌1例、喉癌1例、胰腺癌1例、骨髓发育异常1例）。患癌患者和未患癌患者的系统性硬化症特征相似。然而，3例肺癌与CREST综合征和抗着丝点抗体有关。
