Gouyon J B, Françoise M, Semama D S, Prévot A, d'Athis P, Lallemant C
Laboratoire de Néphrologie-Hémaphérèse-Transplantation, Centre Hospitalier Universitaire, Dijon, France.
Intensive Care Med. 1997 Jun;23(6):677-83. doi: 10.1007/s001340050393.
Comparison of three neonatal hemo(dia)filters (FH22, Gambro; Minifilter Plus, Amicon; Miniflow 10, Hospal) for removal of urea by venovenous hemofiltration (HF) and venovenous hemodiafiltration (HDF).
Filters were successively used for HF with two different blood flows (Qb = 8.3 and 16.6 ml/ min) and for HDF with the two different blood flows and four dialysate flows (Qd = 0.5, 1.0, 2.0, and 3.0 l/h).
21 anesthetized adult New Zealand White rabbits infused with urea.
Urea clearance was significantly increased by HDF compared to HF regardless of blood flow, dialysate flow, and the hemo (dia)filter type except in the FH22 group, when blood flow was high and dialysate flow was 0.5 or 1.0 l/h. The FH22 filter allowed the best urea clearance during HF at high blood flow. During the HDF procedures, the Miniflow 10 allowed the highest urea clearance regardless of blood flow and dialysate flow.
比较三种新生儿血液（透析）滤过器（FH22， Gambro公司；Minifilter Plus，Amicon公司；Miniflow 10，Hospal公司）在静脉-静脉血液滤过（HF）和静脉-静脉血液透析滤过（HDF）中对尿素的清除效果。
滤过器依次用于两种不同血流量（Qb = 8.3和16.6毫升/分钟）的HF以及两种不同血流量和四种透析液流量（Qd = 0.5、1.0、2.0和3.0升/小时）的HDF。
21只输注尿素的成年新西兰白兔。
与HF相比，无论血流量、透析液流量和血液（透析）滤过器类型如何，HDF均能显著提高尿素清除率，但在FH22组中，当血流量高且透析液流量为0.5或1.0升/小时时除外。FH22滤过器在高血流量的HF过程中能实现最佳的尿素清除率。在HDF过程中，无论血流量和透析液流量如何，Miniflow 10的尿素清除率最高。
