Narita T, Kudo H, Matsumoto K
Department of Pathology, Hirosaki University School of Medicine, Japan.
Pathol Int. 1995 May;45(5):383-7. doi: 10.1111/j.1440-1827.1995.tb03472.x.
An extraordinary form of Peyronies disease is reported. The patient was a 52 year old male, who died of a malignant thymoma with multiple bone metastasis, extensive pleural carcinomatosis of the left lung and some metastatic nodules in the liver and the mesenterium. At autopsy, the proximal and middle portions of the penis were very hard. Macroscopically, the entire tunica albuginea of both the corpora cavernosa was markedly thickened, 2-4 mm; and calcified. Microscopically, the tunica albuginea showed extensive hyaline degeneration, calcification and ossifying foci with osteoblasts and osteoclasts. Inflammatory cells were frequently found beneath the thickened tunica albuginea. In the corpus cavernosum, cavernous arteries showed marked intimal thickening and medial muscular degeneration with a few inflammatory cells. Smooth muscles of the stroma were extensively atrophic and degenerative, and some of them were infiltrated with a few inflammatory cells. In the corpus spongiosum, the tunica albuginea was not thickened, but the smooth muscle in the stroma was atrophic and degenerative and a few inflammatory cells were also found. Surprisingly, there was no Littrés gland around the urethra. In Peyronies disease, the dorsal part of the penis is usually involved, and less frequently lateral or ventral sites are involved. The circumferential involvement of both the corpora cavernosa has not been reported until now, as far as the authors know.
报告了佩罗尼氏病的一种特殊形式。患者为一名52岁男性，死于恶性胸腺瘤伴多发骨转移、左肺广泛胸膜癌病以及肝脏和肠系膜的一些转移结节。尸检时，阴茎近端和中部非常坚硬。宏观上，双侧海绵体白膜明显增厚，达2 - 4毫米，并伴有钙化。微观上，白膜显示广泛的透明变性、钙化以及有成骨细胞和破骨细胞的骨化灶。在增厚的白膜下方经常发现炎症细胞。在海绵体内，海绵体动脉显示明显的内膜增厚和中层肌肉变性，伴有少量炎症细胞。间质平滑肌广泛萎缩和变性，其中一些有少量炎症细胞浸润。在尿道海绵体中，白膜未增厚，但间质平滑肌萎缩和变性，也发现了少量炎症细胞。令人惊讶的是，尿道周围没有利特雷腺。在佩罗尼氏病中，阴茎背侧通常受累，而外侧或腹侧部位受累较少。据作者所知，双侧海绵体周向受累至今尚未见报道。
