Capasso A, Aquino R, Garofalo L, De Simone F, Sorrentino L
Department of Pharmaceutical Sciences, University of Salerno, Italy.
J Pharm Pharmacol. 1997 Jul;49(7):712-4. doi: 10.1111/j.2042-7158.1997.tb06097.x.
The effect of indole alkaloids from Sickingia williamsii Standl. (Rubiaceae) on the effects of morphine withdrawal have been examined in-vitro. All the indole alkaloids isolated from S. williamsii (10(-4), 5 x 10(-5) and 10(-5) M) significantly and in a concentration-dependent manner reduced the effects of morphine withdrawal on the guinea-pig ileum. The results suggest that these alkaloids might be potential anti-addictive agents.
对来自威廉希氏茜树（茜草科）的吲哚生物碱对吗啡戒断效应的影响进行了体外研究。从威廉希氏茜树中分离出的所有吲哚生物碱（10⁻⁴、5×10⁻⁵和10⁻⁵M）均以浓度依赖性方式显著降低了吗啡戒断对豚鼠回肠的影响。结果表明，这些生物碱可能是潜在的抗成瘾剂。
