一名艾滋病患者因40型腺病毒F亚属导致慢性肠道感染。

Chronic intestinal infection due to subgenus F type 40 adenovirus in a patient with AIDS.

作者信息

Dionisio D, Arista S, Vizzi E, Manneschi L I, Di Lollo S, Trotta M, Sterrantino G, Mininni S, Leoncini F

机构信息

Infectious Diseases Unit, Careggi Hospital, Florence, Italy.

出版信息

Scand J Infect Dis. 1997;29(3):305-7. doi: 10.3109/00365549709019048.

DOI:10.3109/00365549709019048

PMID:9255895

Abstract

A case of chronic intestinal infection due to adenovirus type 40 lasting for 13 months in a patient with AIDS is described. Adenovirus particles were detected by electron microscopy in biopsy samples taken from the duodenum 3 months after the onset of diarrhoea. The virus was identified as adenovirus type 40 in stool samples by ELISA monoclonal antibodies to adenovirus group antigen (MAd-g2) and types 40 and 41 (MA 40-1 and MA 41-1). No other enteropathogens were found. These data support a causal relationship between adenovirus 40 and the gastrointestinal symptoms of the patient. This is the first reported case of intestinal infection caused by adenovirus type 40 in a patient with AIDS.

摘要

本文描述了一名艾滋病患者因40型腺病毒引起慢性肠道感染长达13个月的病例。腹泻发作3个月后，通过电子显微镜在取自十二指肠的活检样本中检测到腺病毒颗粒。通过针对腺病毒群抗原（MAd-g2）以及40型和41型（MA 40-1和MA 41-1）的ELISA单克隆抗体，在粪便样本中鉴定出该病毒为40型腺病毒。未发现其他肠道病原体。这些数据支持40型腺病毒与该患者胃肠道症状之间存在因果关系。这是首例报道的艾滋病患者由40型腺病毒引起的肠道感染病例。