Lymphotoxins: from cytotoxicity to lymphoid organogenesis.
作者信息
von Boehmer H
机构信息
Institut Necker, Institut National de la Santé et de la Recherche Médicale 373, 156 rue de Vaugirad, F-75730 Paris, Cedex 15, France.
出版信息
Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):8926-7. doi: 10.1073/pnas.94.17.8926.
Abstract
摘要
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本文引用的文献
1
Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice.淋巴毒素β缺陷小鼠次级淋巴组织的异常发育
Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9302-7. doi: 10.1073/pnas.94.17.9302.
2
Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor.派尔集合淋巴结的器官发生是完整的，但在缺乏肿瘤坏死因子及其55 kDa受体的小鼠外周淋巴器官中，B淋巴细胞滤泡的形成存在缺陷。
Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6319-23. doi: 10.1073/pnas.94.12.6319.
3
Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice.淋巴毒素β缺陷小鼠揭示了淋巴毒素α和β在淋巴器官发生中的不同作用。
Immunity. 1997 Apr;6(4):491-500. doi: 10.1016/s1074-7613(00)80292-7.
4
Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs.外周淋巴器官的发育需要表面淋巴毒素α/β复合物。
J Exp Med. 1996 Nov 1;184(5):1999-2006. doi: 10.1084/jem.184.5.1999.
5
Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.肿瘤坏死因子α缺陷小鼠的免疫和炎症反应：肿瘤坏死因子α在初级B细胞滤泡、滤泡树突状细胞网络和生发中心形成以及体液免疫反应成熟过程中的关键需求。
J Exp Med. 1996 Oct 1;184(4):1397-411. doi: 10.1084/jem.184.4.1397.
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Mutant mice without B lymphocyte follicles.没有B淋巴细胞滤泡的突变小鼠。
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Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes.缺乏肿瘤坏死因子受体1的小鼠对肿瘤坏死因子介导的毒性具有抗性，但对单核细胞增生李斯特菌感染高度敏感。
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Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.缺乏55kd肿瘤坏死因子受体的小鼠对内毒素休克具有抗性，但会死于单核细胞增生李斯特菌感染。
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