Rannala B, Mountain J L
Department of Integrative Biology, University of California, Berkeley, CA 94720-3140, USA.
Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9197-201. doi: 10.1073/pnas.94.17.9197.
Immigration is an important force shaping the social structure, evolution, and genetics of populations. A statistical method is presented that uses multilocus genotypes to identify individuals who are immigrants, or have recent immigrant ancestry. The method is appropriate for use with allozymes, microsatellites, or restriction fragment length polymorphisms (RFLPs) and assumes linkage equilibrium among loci. Potential applications include studies of dispersal among natural populations of animals and plants, human evolutionary studies, and typing zoo animals of unknown origin (for use in captive breeding programs). The method is illustrated by analyzing RFLP genotypes in samples of humans from Australian, Japanese, New Guinean, and Senegalese populations. The test has power to detect immigrant ancestors, for these data, up to two generations in the past even though the overall differentiation of allele frequencies among populations is low.
移民是塑造人口社会结构、演变和基因的一股重要力量。本文提出了一种统计方法，该方法利用多位点基因型来识别移民个体或有近期移民祖先的个体。此方法适用于等位酶、微卫星或限制性片段长度多态性（RFLP），并假定基因座间存在连锁平衡。潜在应用包括对动植物自然种群间扩散的研究、人类进化研究以及对来源不明的动物园动物进行分型（用于圈养繁殖计划）。通过分析来自澳大利亚、日本、新几内亚和塞内加尔人群样本中的RFLP基因型对该方法进行了说明。对于这些数据，即使群体间等位基因频率的总体差异较小，该测试仍有能力检测出过去多达两代的移民祖先。
