Littman P, James H, Zimmerman R, Slater R
J Neurol Neurosurg Psychiatry. 1977 Aug;40(8):827-9. doi: 10.1136/jnnp.40.8.827.
A case of radionecrosis of the brain in a patient previously treated for squamous cell carcinoma of the scalp is presented. Cerebral angiography revealed a mass effect primarily in the right frontal area. Computed tomography showed extensive hemispheric oedema. A frontal lobectomy was performed, and the recovery was excellent. The lower limit for brain tolerance for irradiation is about 5000 rads given in five weeks. This dose should not be exceeded when extracranial lesions are treated. Although computed tomography cannot diagnose brain necrosis, specifically, it should, along with the clinical history, be very helpful.
本文介绍了一名曾接受头皮鳞状细胞癌治疗的患者发生脑放射性坏死的病例。脑血管造影显示主要在右额叶区域有占位效应。计算机断层扫描显示广泛的半球水肿。进行了额叶切除术，恢复情况良好。大脑对放疗的耐受下限约为五周内给予5000拉德。治疗颅外病变时不应超过此剂量。虽然计算机断层扫描不能特异性地诊断脑坏死，但结合临床病史应会非常有帮助。
