巨噬细胞对一氧化氮合成的增强代表了两性霉素B的另一种作用机制。
Enhancement of nitric oxide synthesis by macrophages represents an additional mechanism of action for amphotericin B.
作者信息
Mozaffarian N, Berman J W, Casadevall A
机构信息
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
出版信息
Antimicrob Agents Chemother. 1997 Aug;41(8):1825-9. doi: 10.1128/AAC.41.8.1825.
Abstract
Amphotericin B (AmB) enhanced nitrite synthesis by murine macrophage-like J774.16 cells in a dose-dependent fashion. This effect was retained in the presence of Cryptococcus neoformans capsular polysaccharide, a known virulence factor. AmB and anticapsular antibody increased nitrite synergistically. In all cases, AmB required gamma interferon; C. neoformans cells were unable to elicit nitrite, with or without AmB.
摘要
两性霉素B（AmB）可使鼠巨噬细胞样J774.16细胞的亚硝酸盐合成呈剂量依赖性增加。在新型隐球菌荚膜多糖（一种已知的毒力因子）存在的情况下，这种效应依然存在。AmB与抗荚膜抗体可协同增加亚硝酸盐的生成。在所有情况下，AmB都需要γ干扰素；无论有无AmB，新型隐球菌细胞都无法诱导亚硝酸盐的生成。
相似文献
1
Enhancement of nitric oxide synthesis by macrophages represents an additional mechanism of action for amphotericin B.巨噬细胞对一氧化氮合成的增强代表了两性霉素B的另一种作用机制。
Antimicrob Agents Chemother. 1997 Aug;41(8):1825-9. doi: 10.1128/AAC.41.8.1825.
2
Synergic inhibitory activity of amphotericin-B and gamma interferon against intracellular Cryptococcus neoformans in murine macrophages.两性霉素B和γ干扰素对小鼠巨噬细胞内新型隐球菌的协同抑制活性。
J Antimicrob Chemother. 1994 Dec;34(6):1051-8. doi: 10.1093/jac/34.6.1051.
3
Anticryptococcal effect of amphotericin B is mediated through macrophage production of nitric oxide.两性霉素B的抗隐球菌作用是通过巨噬细胞产生一氧化氮来介导的。
Antimicrob Agents Chemother. 1996 Aug;40(8):1919-23. doi: 10.1128/AAC.40.8.1919.
4
Anticryptococcal activity of amphotericin B-stimulated macrophages.两性霉素B刺激的巨噬细胞的抗隐球菌活性。
Immunopharmacol Immunotoxicol. 1991;13(4):465-83. doi: 10.3109/08923979109019717.
5
Cryptococcus neoformans fails to induce nitric oxide synthase in primed murine macrophage-like cells.新型隐球菌无法在致敏的鼠类巨噬细胞样细胞中诱导一氧化氮合酶的产生。
Infect Immun. 1995 Apr;63(4):1298-304. doi: 10.1128/iai.63.4.1298-1304.1995.
6
Amphotericin B and fluconazole affect cellular charge, macrophage phagocytosis, and cellular morphology of Cryptococcus neoformans at subinhibitory concentrations.两性霉素B和氟康唑在亚抑菌浓度下会影响新型隐球菌的细胞电荷、巨噬细胞吞噬作用及细胞形态。
Antimicrob Agents Chemother. 1999 Feb;43(2):233-9. doi: 10.1128/AAC.43.2.233.
7
8
Immune complexes increase nitric oxide production by interferon-gamma- stimulated murine macrophage-like J774.16 cells.免疫复合物可增加经γ-干扰素刺激的鼠巨噬细胞样J774.16细胞的一氧化氮生成量。
J Leukoc Biol. 1995 Apr;57(4):657-62. doi: 10.1002/jlb.57.4.657.
9
In vitro interaction of antifungal and antibacterial drugs against Cryptococcus neoformans var. grubii before and after capsular induction.抗真菌和抗菌药物在诱导荚膜形成前后对新型隐球菌 var. grubii 的体外相互作用。
Med Mycol. 2015 Nov;53(8):885-9. doi: 10.1093/mmy/myv059. Epub 2015 Sep 1.
10
In vitro synergistic effects of chlorpromazine and sertraline in combination with amphotericin B against Cryptococcus neoformans var. grubii.氯丙嗪和舍曲林与两性霉素B联合应用对新型隐球菌格鲁比变种的体外协同作用。
Folia Microbiol (Praha). 2016 Sep;61(5):399-403. doi: 10.1007/s12223-016-0449-8. Epub 2016 Feb 4.
引用本文的文献
1
Regulation of renal nitric oxide and eNOS/iNOS expression by tadalafil participates in the mitigation of amphotericin B-induced renal injury: Down-regulation of NF-κB/iNOS/caspase-3 signaling.他达拉非通过调节肾脏中一氧化氮和 eNOS/iNOS 的表达来减轻两性霉素 B 诱导的肾损伤：下调 NF-κB/iNOS/caspase-3 信号通路。
Naunyn Schmiedebergs Arch Pharmacol. 2024 May;397(5):3141-3153. doi: 10.1007/s00210-023-02787-w. Epub 2023 Oct 28.
2
The Triple Crown: NO, CO, and HS in cancer cell biology.三重冠：癌症细胞生物学中的 NO、CO 和 HS。
Pharmacol Ther. 2023 Sep;249:108502. doi: 10.1016/j.pharmthera.2023.108502. Epub 2023 Jul 28.
3
Repurposing Amphotericin B and Its Liposomal Formulation for the Treatment of Human Mpox.将两性霉素 B 及其脂质体制剂重新用于治疗人类猴痘。
Int J Mol Sci. 2023 May 17;24(10):8896. doi: 10.3390/ijms24108896.
4
It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug.只需一种药物就能发挥多种作用：两性霉素B作为抗真菌和免疫调节药物。
Front Microbiol. 2012 Aug 8;3:286. doi: 10.3389/fmicb.2012.00286. eCollection 2012.
5
Amphotericin B membrane action: role for two types of ion channels in eliciting cell survival and lethal effects.两性霉素 B 的膜作用：两种类型的离子通道在引发细胞存活和致死效应中的作用。
J Membr Biol. 2010 Dec;238(1-3):1-20. doi: 10.1007/s00232-010-9313-y. Epub 2010 Nov 18.
6
In search of the holy grail of antifungal therapy.寻找抗真菌治疗的圣杯。
Trans Am Clin Climatol Assoc. 2008;119:197-215; discussion 215-6.
7
Optimizing efficacy of Amphotericin B through nanomodification.通过纳米修饰优化两性霉素B的疗效。
Int J Nanomedicine. 2007;2(3):301-13.
8
Immune response and immunotherapy to Cryptococcus infections.隐球菌感染的免疫反应与免疫治疗
Immunol Res. 2006;35(3):191-208. doi: 10.1385/IR:35:3:191.
9
Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection.两性霉素B对新型隐球菌在小鼠感染过程中荚膜和细胞大小的影响。
Antimicrob Agents Chemother. 2005 Oct;49(10):4358-61. doi: 10.1128/AAC.49.10.4358-4361.2005.
10
Mechanisms of resistance to oxidative and nitrosative stress: implications for fungal survival in mammalian hosts.抗氧化和亚硝化应激的机制：对真菌在哺乳动物宿主体内生存的影响
Eukaryot Cell. 2004 Aug;3(4):835-46. doi: 10.1128/EC.3.4.835-846.2004.
本文引用的文献
1
Nonencapsulated Variant of Cryptococcus neoformans I. Virulence Studies and Characterization of Soluble Polysaccharide.新型隐球菌非包被变异株 I. 毒力研究及可溶性多糖的特性。
Infect Immun. 1971 Feb;3(2):287-94. doi: 10.1128/iai.3.2.287-294.1971.
2
SERUM PROTEIN ENHANCEMENT OF ANTIBIOTIC THERAPY IN CRYPTOCOCCOSIS.血清蛋白增强抗生素治疗隐球菌病的作用
J Infect Dis. 1964 Oct;114:373-7. doi: 10.1093/infdis/114.4.373.
3
4
Effect of serum IgG1 to Cryptococcus neoformans glucuronoxylomannan on murine pulmonary infection.血清IgG1对新型隐球菌葡糖醛酸木聚糖甘露聚糖在小鼠肺部感染中的作用。
J Immunol. 1997 Jan 15;158(2):790-9.
5
Anticryptococcal effect of amphotericin B is mediated through macrophage production of nitric oxide.两性霉素B的抗隐球菌作用是通过巨噬细胞产生一氧化氮来介导的。
Antimicrob Agents Chemother. 1996 Aug;40(8):1919-23. doi: 10.1128/AAC.40.8.1919.
6
Serotyping of Cryptococcus neoformans by dot enzyme assay.通过斑点酶法对新型隐球菌进行血清分型。
J Clin Microbiol. 1996 Feb;34(2):466-70. doi: 10.1128/jcm.34.2.466-470.1996.
7
Pathology of cryptococcal meningoencephalitis: analysis of 27 patients with pathogenetic implications.隐球菌性脑膜脑炎的病理学：对27例患者的分析及发病机制探讨
Hum Pathol. 1996 Aug;27(8):839-47. doi: 10.1016/s0046-8177(96)90459-1.
8
Expression of inducible nitric oxide synthase in rat pulmonary Cryptococcus neoformans granulomas.诱导型一氧化氮合酶在大鼠肺部新型隐球菌肉芽肿中的表达
Am J Pathol. 1996 Apr;148(4):1275-82.
9
10
Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis.肺结核患者肺泡巨噬细胞中的诱导型一氧化氮合酶
J Exp Med. 1996 May 1;183(5):2293-302. doi: 10.1084/jem.183.5.2293.
Zotero 插件