巨噬细胞对一氧化氮合成的增强代表了两性霉素B的另一种作用机制。
Enhancement of nitric oxide synthesis by macrophages represents an additional mechanism of action for amphotericin B.
作者信息
Mozaffarian N, Berman J W, Casadevall A
机构信息
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
出版信息
Antimicrob Agents Chemother. 1997 Aug;41(8):1825-9. doi: 10.1128/AAC.41.8.1825.
Abstract
Amphotericin B (AmB) enhanced nitrite synthesis by murine macrophage-like J774.16 cells in a dose-dependent fashion. This effect was retained in the presence of Cryptococcus neoformans capsular polysaccharide, a known virulence factor. AmB and anticapsular antibody increased nitrite synergistically. In all cases, AmB required gamma interferon; C. neoformans cells were unable to elicit nitrite, with or without AmB.
摘要
两性霉素B（AmB）可使鼠巨噬细胞样J774.16细胞的亚硝酸盐合成呈剂量依赖性增加。在新型隐球菌荚膜多糖（一种已知的毒力因子）存在的情况下，这种效应依然存在。AmB与抗荚膜抗体可协同增加亚硝酸盐的生成。在所有情况下，AmB都需要γ干扰素；无论有无AmB，新型隐球菌细胞都无法诱导亚硝酸盐的生成。
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