Hosoda S, Suzuki K, Sudo K, Yoshida N, Tanaka C
J Natl Cancer Inst. 1979 Dec;63(6):1447-50.
A transplantable strain of gastric carcinoids of Mastomys (Praomys) natalensis secreted not only histamine but also serotonin [5-hydroxytryptamine (5-HT)]. Mastomys bearing growing transplants excreted 11.3 times more histamine and 4.4 times more 5-hydroxyindole-3-acetic acid (5-HIAA) in the urine than did Mastomys in which transplanted tumors did not grow. Mastomys that developed primary gastric carcinoids also excreted 3.9 times more histamine than did those free from primary tumors, but the difference in urinary excretion of 5-HIAA was not significant in both groups. All transplantable carcinoids contained definite amounts of both histamine and serotonin, whereas the primary gastric carcinoids contained only histamine. We also confirmed that the histamine and 5-HIAA excreted in urine increased as the size of transplanted tumors enlarged. 5-HT was histochemically demonstrated in a small number of carcinoid cells of the transplanted tumors but not in primary carcinoids.
南非多乳鼠（原稻鼠属）的一种可移植性胃类癌菌株不仅分泌组胺，还分泌5-羟色胺[5-羟色胺（5-HT）]。携带生长中移植瘤的南非多乳鼠尿液中组胺排泄量比移植瘤未生长的南非多乳鼠高11.3倍，5-羟吲哚-3-乙酸（5-HIAA）排泄量高4.4倍。发生原发性胃类癌的南非多乳鼠组胺排泄量也比无原发性肿瘤的南非多乳鼠高3.9倍，但两组5-HIAA的尿排泄差异不显著。所有可移植类癌都含有一定量的组胺和5-羟色胺，而原发性胃类癌仅含有组胺。我们还证实，随着移植瘤大小的增大，尿中排泄的组胺和5-HIAA增加。在移植瘤的少数类癌细胞中通过组织化学方法证实有5-HT，但在原发性类癌中未发现。
