Estimation of pharmacokinetic parameters from postinfusion blood level data obtained after simultaneous administration of intravenous priming and infusion doses.

Occasionally, it is desirable to attain steady-state-state blood drug levels rapidly in pharmacokinetic studies as well as in the treatment of certain diseases. In these cases, it is useful to administer an intravenous priming dose in combination with continuous drug infusion. Mathematical relationships are presented for the determination of pharmacokinetic parameters in these situations using postinfusion blood drug level data. The parameters obtained by this method are identical to the parameters obtained after a rapid intravenous injection of a drug.