Vandorpe J, Schacht E, Dunn S, Hawley A, Stolnik S, Davis S S, Garnett M C, Davies M C, Illum L
Department of Organic Chemistry, Biomaterials and Polymer Research Group, University of Ghent, Belgium.
Biomaterials. 1997 Sep;18(17):1147-52. doi: 10.1016/s0142-9612(97)00052-5.
The biodistribution of biodegradable poly(organo phosphazene) nanoparticles surface modified by adsorption of a novel poly(organo phosphazene)-poly(ethylene oxide) copolymer with a 5000 M(W) PEO chain (PF-PEO[5000]), following intravenous administration in rats and rabbits, is described. The data are compared to the biodistribution of poly(organo phosphazene) and poly(lactide-co-glycolide) nanoparticles coated with a tetrafunctional copolymer of poly(ethylene oxide)-poly(propylene oxide) ethylenediamine, commercially available as Poloxamine 908. This copolymer has a PEO chain of the same size as the poly(organo phosphazene)-PEO derivative used. The results in the rat model reveal that poly(organo phosphazene) nanoparticles with a Poloxamine 908 coating were mainly captured by the liver, although a retardation in clearance from the systemic circulation was seen. In contrast, the poly(organo phosphazene) nanoparticles coated with PF-PEO(5000) showed a prolonged blood circulating profile, with only a small amount of the nanoparticles sequestered by the liver. This indicates the importance of the nature of both the anchoring group and the particle surface on the biological performances of the system. Study of the biodistribution of the PF-PEO(5000)-coated poly(organo phosphazene) nanoparticles in the rabbit model also indicated a prolonged systemic circulation lifetime and reduced liver uptake, whereby a significant amount of the administered nanoparticles was targeted to the bone marrow.
描述了一种新型聚（有机磷腈）-聚（环氧乙烷）共聚物（PEO链分子量为5000，PF-PEO[5000]）吸附修饰的可生物降解聚（有机磷腈）纳米颗粒在大鼠和兔子静脉注射后的生物分布情况。将这些数据与涂覆有聚（环氧乙烷）-聚（环氧丙烷）乙二胺四官能共聚物（商品名为泊洛沙明908）的聚（有机磷腈）和聚（丙交酯-乙交酯）纳米颗粒的生物分布进行了比较。该共聚物的PEO链大小与所使用的聚（有机磷腈）-PEO衍生物相同。大鼠模型的结果表明，涂覆有泊洛沙明908的聚（有机磷腈）纳米颗粒主要被肝脏捕获，尽管从体循环中的清除有所延迟。相比之下，涂覆有PF-PEO(5000)的聚（有机磷腈）纳米颗粒显示出延长的血液循环曲线，只有少量纳米颗粒被肝脏截留。这表明锚定基团和颗粒表面的性质对该系统生物学性能的重要性。对涂覆有PF-PEO(5000)的聚（有机磷腈）纳米颗粒在兔子模型中的生物分布研究也表明其体循环寿命延长且肝脏摄取减少，从而大量给药的纳米颗粒靶向至骨髓。
