Mastrobattista J M, Skupski D W, Monga M, Blanco J D, August P
Department of Obstetrics, University of Texas Medical School at Houston 77030, USA.
Am J Perinatol. 1997 May;14(5):263-5. doi: 10.1055/s-2007-994140.
The objective of this study was to determine if the rate of preeclampsia is increased in triplet as compared to twin gestations. Fifty-three triplet pregnancies between 1986 and 1993 at The New York Hospital-Cornell Medical Center were reviewed. These were matched for maternal age, parity, and race to twin gestations (N = 53) from the same population. Severe preeclampsia was defined by standard criteria. Student's t-test, Fisher exact test, and Chi-square were used for statistical analysis. The rate of severe preeclampsia was increased significantly in the triplet group 12 of 53 (22.6%) as compared with the twin group 3 of 53 (5.7%) (OR = 4.9, 95% CI 1.2-23.5, p = 0.02). The rate of overall preeclampsia was not significantly different in the triplet 18 of 53 (33.96%) or twin 12 of 53 (22.6%) groups. In this retrospective, case-controlled study, the rate of severe pre-eclampsia was significantly increased in triplet gestations as compared to twins although the overall rate of preeclampsia was not. This information may be useful in counseling patients with high order multifetal gestations.
本研究的目的是确定与双胎妊娠相比，三胎妊娠时子痫前期的发生率是否增加。回顾了1986年至1993年在纽约医院-康奈尔医学中心的53例三胎妊娠病例。将这些病例与来自同一人群的双胎妊娠（N = 53）在产妇年龄、产次和种族方面进行匹配。重度子痫前期采用标准标准定义。采用学生t检验、Fisher精确检验和卡方检验进行统计分析。与双胎组53例中的3例（5.7%）相比，三胎组53例中的12例（22.6%）重度子痫前期的发生率显著增加（OR = 4.9，95%CI 1.2 - 23.5，p = 0.02）。三胎组53例中的18例（33.96%）和双胎组53例中的12例（22.6%）的总体子痫前期发生率无显著差异。在这项回顾性病例对照研究中，与双胎相比，三胎妊娠时重度子痫前期的发生率显著增加，尽管子痫前期的总体发生率没有增加。这些信息可能有助于为高阶多胎妊娠患者提供咨询。
