Toole B P
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA, USA.
J Intern Med. 1997 Jul;242(1):35-40. doi: 10.1046/j.1365-2796.1997.00171.x.
Pericellular matrices surrounding migrating and proliferating cells in the developing embryo, in regenerating tissues and in other dynamic cellular events, such as tumour cell invasion, are enriched in hyaluronan. In addition to contributing to the unique structure of the pericellular matrix, hyaluronan interacts with cell surface receptors, such as RHAMM and CD44. During morphogenesis, these interactions of hyaluronan with the cell surface are important in several ways. First, hyaluronan-CD44 interactions have been shown to mediate endocytic removal of hyaluronan at critical stages of embryonic development. Secondly, hyaluronan provides an appropriately hydrated, pericellular milieu that facilitates cellular invasion. Thirdly, in-vitro studies suggest strongly that interactions of hyaluronan with RHAMM or CD44 are involved in cell movement and proliferation, which are critical events in morphogenesis.
在发育中的胚胎、再生组织以及其他动态细胞事件（如肿瘤细胞侵袭）中，围绕迁移和增殖细胞的细胞周基质富含透明质酸。除了有助于细胞周基质的独特结构外，透明质酸还与细胞表面受体（如RHAMM和CD44）相互作用。在形态发生过程中，透明质酸与细胞表面的这些相互作用在几个方面都很重要。首先，透明质酸与CD44的相互作用已被证明在胚胎发育的关键阶段介导透明质酸的内吞清除。其次，透明质酸提供了一个水合适度的细胞周环境，有利于细胞侵袭。第三，体外研究有力地表明，透明质酸与RHAMM或CD44的相互作用参与细胞运动和增殖，而这是形态发生中的关键事件。
