Dandona P, James I M, Woollard M L, Newbury P, Beckett A G
Lancet. 1979 Dec 8;2(8154):1203-5. doi: 10.1016/s0140-6736(79)92330-4.
Cerebral blood-flow (CBF) was measured in 23 insulin-dependent diabetics before and 2--3 h after insulin/breakfast. In 10 of these patients CBF changed significantly during the day, with a significant fall in 9. In 3 patients who had the greatest falls in CBF there was a concomitant sensation of an impending faint. Thus CBF is unstable in insulin-dependent diabetics in contrast to control subjects in who there is little or no variation. Sudden falls in CBF in insulin-dependent diabetics may explain the symptoms of impending faint without hypoglycaemia; such falls would also be relevant to the pathogenesis of strokes in these patients.
对23名胰岛素依赖型糖尿病患者在胰岛素/早餐前及之后2 - 3小时测量了脑血流量（CBF）。其中10名患者的CBF在一天中发生了显著变化，9名患者的CBF显著下降。在CBF下降幅度最大的3名患者中，同时伴有即将昏厥的感觉。因此，与几乎没有或没有变化的对照受试者相比，胰岛素依赖型糖尿病患者的CBF不稳定。胰岛素依赖型糖尿病患者CBF的突然下降可能解释了无低血糖情况下即将昏厥的症状；这种下降也与这些患者中风的发病机制有关。
