糖尿病中的脑血流量：脑血管反应异常的证据。
Cerebral blood flow in diabetes mellitus: evidence of abnormal cerebrovascular reactivity.
作者信息
Dandona P, James I M, Newbury P A, Woollard M L, Beckett A G
出版信息
Br Med J. 1978 Jul 29;2(6133):325-6. doi: 10.1136/bmj.2.6133.325.
Abstract
Cerebral blood flow (CBF) was studied at normocapnia and after a challenge with 5% CO2 in 59 diabetic patients and 28 controls. There was a significant age-related decline in CBF in both groups, which suggests that diabetes does not affect the rate of decrease of CBF with age. After CO2 challenge CBF increased in most of the controls; in the patients CBF increased in 23, decreased in 26, and remained stable in 10. Thus the reactivity of cerebral blood vessels in diabetics is altered. Diabetics have diminished cerebrovascular reserve and are thus at increased risk of cerebrovascular disease because they are unable to compensate when necessary with an increased CBF.
摘要
对59例糖尿病患者和28例对照者在正常碳酸血症时及用5%二氧化碳激发后进行了脑血流量（CBF）研究。两组的CBF均随年龄显著下降，这表明糖尿病并不影响CBF随年龄的下降速率。二氧化碳激发后，大多数对照者的CBF增加；在患者中，23例CBF增加，26例CBF减少，10例保持稳定。因此，糖尿病患者脑血管的反应性发生了改变。糖尿病患者脑血管储备减少，因此患脑血管疾病的风险增加，因为他们在必要时无法通过增加CBF进行代偿。
相似文献
1
Cerebral blood flow in diabetes mellitus: evidence of abnormal cerebrovascular reactivity.糖尿病中的脑血流量：脑血管反应异常的证据。
Br Med J. 1978 Jul 29;2(6133):325-6. doi: 10.1136/bmj.2.6133.325.
2
3
The dose effect of propofol on cerebrovascular reactivity to carbon dioxide in rabbits.异丙酚对兔脑血管二氧化碳反应性的剂量效应
Acta Anaesthesiol Sin. 1999 Mar;37(1):3-8.
4
Instability of cerebral blood-flow in insulin-dependent diabetics.胰岛素依赖型糖尿病患者脑血流的不稳定性。
Lancet. 1979 Dec 8;2(8154):1203-5. doi: 10.1016/s0140-6736(79)92330-4.
5
Cerebrovascular CO2 reactivity after carotid artery occlusion.颈动脉闭塞后脑血管二氧化碳反应性
J Neurosurg. 1988 Jul;69(1):24-8. doi: 10.3171/jns.1988.69.1.0024.
6
Effects of nicardipine-induced hypotension on cerebrovascular carbon dioxide reactivity in patients with diabetes mellitus under sevoflurane anesthesia.尼卡地平诱导的低血压对七氟醚麻醉下糖尿病患者脑血管二氧化碳反应性的影响。
J Anesth. 2007;21(2):125-30. doi: 10.1007/s00540-007-0500-7. Epub 2007 May 30.
7
MK-801 does not prevent impaired cerebrovascular reactivity to CO2 during hypoglycemia in piglets.MK-801不能预防仔猪低血糖期间脑血管对二氧化碳的反应性受损。
Am J Physiol. 1993 Jun;264(6 Pt 2):H2124-30. doi: 10.1152/ajpheart.1993.264.6.H2124.
8
The comparative effects of sevoflurane versus isoflurane on cerebrovascular carbon dioxide reactivity in patients with diabetes mellitus.七氟醚与异氟醚对糖尿病患者脑血管二氧化碳反应性的比较效应
Anesth Analg. 2006 Jul;103(1):168-72, table of contents. doi: 10.1213/01.ane.0000221188.09510.75.
9
Cerebral blood flow responsivity to CO2 in anesthetized chronically diabetic dogs.
Am J Physiol. 1993 Apr;264(4 Pt 2):H1069-75. doi: 10.1152/ajpheart.1993.264.4.H1069.
10
CO2 reactivity and heterogeneity of cerebral blood flow in ischemic, border zone, and normal cortex.缺血、边缘区及正常皮层中二氧化碳反应性及脑血流的异质性
Am J Physiol. 1989 Aug;257(2 Pt 2):H473-82. doi: 10.1152/ajpheart.1989.257.2.H473.
引用本文的文献
1
Diabetes and Ischemic Stroke: An Old and New Relationship an Overview of the Close Interaction between These Diseases.糖尿病与缺血性脑卒中：一种古老而又崭新的关系——浅析这两种疾病之间的密切关联。
Int J Mol Sci. 2022 Feb 21;23(4):2397. doi: 10.3390/ijms23042397.
2
Reproducibility of cerebrovascular reactivity measurements: A systematic review of neuroimaging techniques.脑血管反应性测量的可重复性：神经影像学技术的系统评价。
J Cereb Blood Flow Metab. 2022 May;42(5):700-717. doi: 10.1177/0271678X211056702. Epub 2021 Nov 22.
3
Hemodynamic and oxygen-metabolic responses of the awake mouse brain to hypercapnia revealed by multi-parametric photoacoustic microscopy.多参数光声显微镜揭示清醒小鼠大脑对高碳酸血症的血液动力学和氧代谢反应。
J Cereb Blood Flow Metab. 2021 Oct;41(10):2628-2639. doi: 10.1177/0271678X211010352. Epub 2021 Apr 25.
4
Cerebral vs. Cardiovascular Responses to Exercise in Type 2 Diabetic Patients.2型糖尿病患者运动时的脑与心血管反应
Front Physiol. 2021 Jan 15;11:583155. doi: 10.3389/fphys.2020.583155. eCollection 2020.
5
Cerebral Oxygenation during Exercise in Patients with Cardiopulmonary Diseases: A Prospective Observational Study.心肺疾病患者运动期间的脑氧合：一项前瞻性观察研究。
Acta Cardiol Sin. 2020 Nov;36(6):667-674. doi: 10.6515/ACS.202011_36(6).20200519C.
6
Cardiovascular disease risk is associated with middle cerebral artery blood flow velocity in older adults.心血管疾病风险与老年人的大脑中动脉血流速度相关。
Cardiopulm Phys Ther J. 2020 Apr;31(2):38-46. doi: 10.1097/cpt.0000000000000110.
7
Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish.硝普钠可防止葡萄糖对斑马鱼神经血管单元和行为的有害影响。
Dis Model Mech. 2019 Sep 25;12(9):dmm039867. doi: 10.1242/dmm.039867.
8
Technology Development for Simultaneous Wearable Monitoring of Cerebral Hemodynamics and Blood Pressure.同时监测脑血流动力学和血压的可穿戴技术的发展。
IEEE J Biomed Health Inform. 2019 Sep;23(5):1952-1963. doi: 10.1109/JBHI.2018.2876087. Epub 2018 Oct 15.
9
Reduced Regional Cerebral Blood Flow Relates to Poorer Cognition in Older Adults With Type 2 Diabetes.脑血流量减少与老年2型糖尿病患者认知能力较差有关。
Front Aging Neurosci. 2018 Sep 10;10:270. doi: 10.3389/fnagi.2018.00270. eCollection 2018.
10
Cerebral metabolism and vascular reactivity during breath-hold and hypoxic challenge in freedivers and healthy controls.屏气和低氧挑战期间自由潜水员和健康对照者的脑代谢和血管反应性。
J Cereb Blood Flow Metab. 2019 May;39(5):834-848. doi: 10.1177/0271678X17737909. Epub 2017 Nov 3.
本文引用的文献
1
Determination of regional cerebral blood flow by inhalation of 133-Xenon.通过吸入133-氙测定局部脑血流量。
Circ Res. 1967 Jan;20(1):124-35. doi: 10.1161/01.res.20.1.124.
2
The measurement of regional cerebral clearance rates in man using xenon-133 inhalation and extracranial recording.
Clin Sci. 1965 Aug;29(1):179-91.
3
Regional cerebral blood flow: a comparison of 8-detector and 16-detector instrumentation.
J Nucl Med. 1969 Apr;10(4):164-73.
4
Recent developments in the 133xenon inhalation technique for cerebral flow.用于脑血流的133氙吸入技术的最新进展。
J Nucl Biol Med. 1975 Oct-Dec;19(4):205-12.
5
The construction and use of nomograms for cerebral blood flow calculation using a 133Xe inhalation technique.
Phys Med Biol. 1976 May;21(3):406-13. doi: 10.1088/0031-9155/21/3/006.
6
Two minute slope inhalation technique for cerebral blood flow measurement in man. 1. Method.用于人体脑血流测量的两分钟斜坡吸入技术。1. 方法。
J Neurol Neurosurg Psychiatry. 1976 Feb;39(2):141-6. doi: 10.1136/jnnp.39.2.141.
7
Is hyperviscosity a treatable component of diabetic microcirculatory disease?高黏滞血症是糖尿病微血管疾病的一个可治疗的组成部分吗？
Lancet. 1977 Oct 15;2(8042):789-91. doi: 10.1016/s0140-6736(77)90724-3.
Zotero 插件