糖尿病中的脑血流量：脑血管反应异常的证据。
Cerebral blood flow in diabetes mellitus: evidence of abnormal cerebrovascular reactivity.
作者信息
Dandona P, James I M, Newbury P A, Woollard M L, Beckett A G
出版信息
Br Med J. 1978 Jul 29;2(6133):325-6. doi: 10.1136/bmj.2.6133.325.
Abstract
Cerebral blood flow (CBF) was studied at normocapnia and after a challenge with 5% CO2 in 59 diabetic patients and 28 controls. There was a significant age-related decline in CBF in both groups, which suggests that diabetes does not affect the rate of decrease of CBF with age. After CO2 challenge CBF increased in most of the controls; in the patients CBF increased in 23, decreased in 26, and remained stable in 10. Thus the reactivity of cerebral blood vessels in diabetics is altered. Diabetics have diminished cerebrovascular reserve and are thus at increased risk of cerebrovascular disease because they are unable to compensate when necessary with an increased CBF.
摘要
对59例糖尿病患者和28例对照者在正常碳酸血症时及用5%二氧化碳激发后进行了脑血流量（CBF）研究。两组的CBF均随年龄显著下降，这表明糖尿病并不影响CBF随年龄的下降速率。二氧化碳激发后，大多数对照者的CBF增加；在患者中，23例CBF增加，26例CBF减少，10例保持稳定。因此，糖尿病患者脑血管的反应性发生了改变。糖尿病患者脑血管储备减少，因此患脑血管疾病的风险增加，因为他们在必要时无法通过增加CBF进行代偿。
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