Shimada A, Mukhin A, Ingram D K, London E D
Molecular Physiology and Genetics Section, National InstitUte on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Neurobiol Aging. 1997 May-Jun;18(3):329-33. doi: 10.1016/s0197-4580(97)80315-6.
Potential age differences in N-methyl-D-aspartate (NMDA) receptor binding were evaluated in rat brain using [3H]dizocilpine and [3H]D,L-(E)-2-amino-4-propyl-5-phosphono-3-pentanoic acid (CGP 39653) as the radioligands. Neither [3H]dizocilpine nor [3H]CGP 39653 binding in hippocampus revealed any age difference (7 vs. 23-25 months) in Bmax or Kd. High-affinity [3H]dizocilpine binding showed a developmental increase (8 vs. 2 months) in hippocampus but not in frontal cortex. No senescence-related change (25 vs. 8 months) was observed in either region. The lack of senescence-related differences in these biochemical markers does not preclude the possibility of functional changes in the NMDA receptor with aging.
