Gardner M L, Earl S D, Wood D
Department of Biomedical Sciences, University of Bradford, West Yorkshire, United Kingdom.
Nutrition. 1997 Jul-Aug;13(7-8):755-9. doi: 10.1016/s0899-9007(97)83040-7.
We have investigated the possible benefits of elemental diets, especially a diet supplemented with L-glutamine, on maintenance of intestinal absorptive function in rat small intestine damaged by 5-fluorouracil. Although a standard rat diet sustained better body growth in control rats, each of the elemental diets and the diet containing intact casein in place of hydrolyzed casein was beneficial in promoting less body weight loss during the 3 d after 5-fluorouracil injection. The same significant benefit was seen in absorptive activity measured in small intestine in vitro 3 d after the cytotoxic injury. Glutamine supplementation, however, did not confer any significant advantages, although it did cause significant elevation of muscle glutamine pools. This elevation was substantially less than the corresponding increase in muscle glycine content after dietary supplementation with glycine.
我们研究了要素饮食，尤其是补充L-谷氨酰胺的饮食，对5-氟尿嘧啶损伤的大鼠小肠肠道吸收功能维持的潜在益处。尽管标准大鼠饮食能使对照大鼠的身体生长状况更好，但在注射5-氟尿嘧啶后的3天内，每种要素饮食以及用完整酪蛋白替代水解酪蛋白的饮食都有助于减少体重减轻。在细胞毒性损伤后3天，体外小肠吸收活性的测量结果显示了同样显著的益处。然而，补充谷氨酰胺并没有带来任何显著优势，尽管它确实使肌肉谷氨酰胺池显著升高。与饮食中补充甘氨酸后肌肉甘氨酸含量的相应增加相比，这种升高幅度要小得多。
