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连续妊娠中的胎儿肾盂扩张:一种可能的遗传易感性。

Fetal pyelectasis in consecutive pregnancies: a possible genetic predisposition.

作者信息

Degani S, Leibovitz Z, Shapiro I, Gonen R, Ohel G

机构信息

Department of Obstetrics and Gynecology, Bnai-Zion Medical Center, Haifa, Israel.

出版信息

Ultrasound Obstet Gynecol. 1997 Jul;10(1):19-21. doi: 10.1046/j.1469-0705.1997.10010019.x.

DOI:10.1046/j.1469-0705.1997.10010019.x
PMID:9263418
Abstract

Mild fetal pyelectasis is a relatively common finding. The objective of this study was to assess its recurrence rate in subsequent pregnancies. The study comprised 420 women with two consecutive normal uncomplicated pregnancies screened at 15-24 weeks' gestation by ultrasound. Pyelectasis was defined as a fetal pelvis of 4 mm or more in its anterior-posterior dimensions. Of 64 fetuses with pyelectasis, 43 (67%) had a recurrence of this finding in their subsequent pregnancy. Compared with normal fetuses, those with pyelectasis had a relative risk of 6.1 to have a recurrence of this finding in their next pregnancy (95% confidence interval, 4.3-7.5, p < 0.001). These results suggest a predisposition for pyelectusis that may be influenced by genetic and/or environmental factors. More data are needed before an accurate adjustment based on previous results can be made.

摘要

轻度胎儿肾盂扩张是一种相对常见的表现。本研究的目的是评估其在后续妊娠中的复发率。该研究纳入了420名在妊娠15 - 24周时接受超声检查的连续两次正常无并发症妊娠的女性。肾盂扩张定义为胎儿肾盂前后径达4毫米或以上。在64例有肾盂扩张的胎儿中,43例(67%)在其后续妊娠中出现了该表现的复发。与正常胎儿相比,有肾盂扩张的胎儿在下一次妊娠中出现该表现复发的相对风险为6.1(95%置信区间,4.3 - 7.5,p < 0.001)。这些结果提示肾盂扩张可能存在易患倾向,可能受遗传和/或环境因素影响。在根据先前结果进行准确调整之前,还需要更多数据。

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