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为何同源框基因成簇排列?

Why are Hox genes clustered?

作者信息

Mann R S

机构信息

Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

出版信息

Bioessays. 1997 Aug;19(8):661-4. doi: 10.1002/bies.950190804.

Abstract

The evolutionarily conserved genomic organization of the Hox genes has been a puzzle ever since it was discovered that their order along the chromosome is similar to the order of their functional domains along the antero-posterior axis. Why has this colinearity been maintained throughout evolution? A close look at regulatory sequences from the mouse Hox clusters suggests that enhancer sharing between adjacent Hox genes may be one reason. Moreover, characterizing the activity of one of these mouse enhancers in Drosophila illustrates that despite many similarities, not all Hox clusters are built in the same way.

摘要

自发现Hox基因沿染色体的顺序与其沿前后轴的功能域顺序相似以来,其进化上保守的基因组组织一直是个谜。为什么这种共线性在整个进化过程中得以维持?仔细研究小鼠Hox簇的调控序列表明,相邻Hox基因之间共享增强子可能是一个原因。此外,对果蝇中这些小鼠增强子之一的活性进行表征表明,尽管存在许多相似之处,但并非所有Hox簇的构建方式都相同。

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