Parham G, Phillips J L, Hicks M L, Andrews N, Jones W B, Shingleton H M, Menck H R
Department of Obstetrics and Gynecology, University of Arkansas College of Medical Science, Little Rock, USA.
Cancer. 1997 Aug 15;80(4):816-26.
Epithelial ovarian carcinoma is the fifth most common cause of cancer death among African-American women. Although the incidence rate of ovarian carcinoma for whites is higher than that for African Americans, the relative survival rate for African Americans is poorer.
Data were cases submitted to the National Cancer Data Base for invasive epithelial tumors of the ovary diagnosed between 1985-1988 and 1990-1993. African-American women with epithelial ovarian carcinoma were compared with non-Hispanic white women with the same disease. The groups of white women with which African-American women were compared were classified as "White-same facility" and "White-other facility." "White-same facility" were white patients from hospitals that contributed a substantial proportion of African-American patients. "White-other facility" were white patients from hospitals that contributed few or no African-American patients. No patient had a history of prior cancer.
African-American women with advanced invasive epithelial ovarian carcinoma were less often treated with combined surgery and chemotherapy and more often treated with chemotherapy only. African-American women were twice as likely as white women not to receive appropriate treatment. African-American women had poorer survival rates than white women from the same or different hospitals, regardless of income. Among staged cases, African-American women were more often diagnosed with Stage IV disease than either group of white women.
The current study findings show that African-American women with advanced epithelial ovarian carcinoma received less aggressive treatment than white women and had a poorer prognosis.
上皮性卵巢癌是非洲裔美国女性中癌症死亡的第五大常见原因。尽管白人卵巢癌的发病率高于非裔美国人，但非裔美国人的相对生存率更低。
数据来源于1985 - 1988年和1990 - 1993年间提交至国家癌症数据库的卵巢浸润性上皮肿瘤病例。将患有上皮性卵巢癌的非裔美国女性与患有相同疾病的非西班牙裔白人女性进行比较。与非裔美国女性进行比较的白人女性组被分为“白人 - 同一机构”和“白人 - 其他机构”。“白人 - 同一机构”是来自那些有相当比例非裔美国患者的医院的白人患者。“白人 - 其他机构”是来自那些很少或没有非裔美国患者的医院的白人患者。没有患者有既往癌症病史。
患有晚期浸润性上皮性卵巢癌的非裔美国女性接受联合手术和化疗的频率较低，更多的是仅接受化疗。非裔美国女性不接受适当治疗的可能性是白人女性的两倍。无论收入如何，非裔美国女性的生存率都低于来自同一或不同医院的白人女性。在分期病例中，非裔美国女性比任何一组白人女性更常被诊断为IV期疾病。
当前的研究结果表明，患有晚期上皮性卵巢癌的非裔美国女性比白人女性接受的积极治疗更少，预后更差。
