Tevi-Bénissan C, Grésenguet G, Si Mohamed A, Bélec L
Laboratoire de virologie, Hôpital Broussais, Paris, France.
Bull Soc Pathol Exot. 1997;90(1):39-43.
Cervicovaginal secretions (CVS) from 46 heterosexual African women, attending the National Reference Center for Sexually Transmitted Diseases and AIDS of Bangui, Central African Republic, were investigated, at inclusion and after vaginal douching with water, in order, i) to determine the relationship between cervicovaginal pH and the presence of semen components [prostatic acid phosphatase (PAP) and prostatic specific antigen (PSA)] in sexually active African women; ii) to assess whether vaginal douching performed after sexual intercourse could efficiently eliminate semen components and restore cervicovaginal acid pH. At inclusion, semen components were found in 41 CVS (89%); the mean cervicovaginal pH was 6.12 (range, 3.86 to 8.33); concentrations of both PAP and PSA correlated positively and strongly with cervicovaginal pH (p < 0.001). After douching, semen components were found in only 31 CVS (67%) (p < 0.03); vaginal PAP and PSA levels were significantly decreased (p < 0.0001); PAP: -21%; PSA: -36%). Frequent persistence of semen in cervicovaginal secretions from heterosexually active African women leads to a shift from acidity to neutrality, that could favor male-to-female HIV transmission.
对来自中非共和国班吉市国家性传播疾病和艾滋病参考中心的46名异性恋非洲女性的宫颈阴道分泌物（CVS）进行了研究，在纳入研究时以及用水进行阴道灌洗后，目的如下：i）确定性活跃的非洲女性宫颈阴道pH值与精液成分[前列腺酸性磷酸酶（PAP）和前列腺特异性抗原（PSA）]存在之间的关系；ii）评估性交后进行阴道灌洗是否能有效清除精液成分并恢复宫颈阴道酸性pH值。在纳入研究时，在41份CVS中发现了精液成分（89%）；宫颈阴道平均pH值为6.12（范围为3.86至8.33）；PAP和PSA的浓度与宫颈阴道pH值呈强正相关（p<0.001）。灌洗后，仅在31份CVS中发现了精液成分（67%）（p<0.03）；阴道PAP和PSA水平显著降低（p<0.0001）；PAP：-21%；PSA：-36%）。性活跃的非洲女性宫颈阴道分泌物中精液的频繁残留会导致从酸性转变为中性，这可能有利于艾滋病毒从男性传播给女性。
