Locke S E, Ransil B J, Zachariae R, Molay F, Tollins K, Covino N A, Danforth D
Department of Psychiatry, Beth Israel Hospital, Boston, MA 02215.
JAMA. 1994 Jul 6;272(1):47-52.
To determine whether individuals selected for good general health, high hypnotizability, and the ability to alter skin temperature under hypnotic suggestion can influence the delayed-type hypersensitivity (DTH) response to varicella-zoster (VZ) antigen under hypnotic suggestion.
A blinded clinical trial using a repeated measures design with subjects serving as their own controls. Subjects were randomly assigned to undergo a predetermined sequence of four different experimental conditions, occurring at weekly intervals, with each condition including VZ skin testing: (1) hypnosis with suggestions to enhance the DTH response to VZ antigen; (2) hypnosis with suggestions to suppress the DTH response; (3) hypnosis with suggestions for relaxation only; and (4) skin testing without hypnosis.
A National Institutes of Health-supported clinical research center in a teaching hospital.
A stratified sample of 24 ambulatory, healthy, highly hypnotizable, volunteer college students selected for their above-average ability to alter skin temperature after hypnotic suggestions and their positive baseline responses to VZ antigen. There were 11 males and 13 females with a mean +/- SD age of 22 +/- 6 years. The mean +/- SD hypnotizability score (Harvard Group Scale of Hypnotic Susceptibility) was 11 +/- 1.
Intradermal skin testing with VZ antigen (Mantoux method) and hypnotic suggestion.
Areas of induration of the DTH response measured at 24 and 48 hours after injection of antigen.
The area of the DTH response was not affected by the experimental interventions. The area of erythema was likewise unaffected.
Our subjects were unable to alter their DTH responses using hypnotic suggestion.
确定那些因总体健康状况良好、高催眠易感性以及在催眠暗示下能够改变皮肤温度而被选中的个体，在催眠暗示下是否能影响对水痘 - 带状疱疹（VZ）抗原的迟发型超敏反应（DTH）。
一项采用重复测量设计的盲法临床试验，受试者自身作为对照。受试者被随机分配接受按预定顺序进行的四种不同实验条件，每周进行一次，每种条件都包括VZ皮肤测试：（1）进行增强对VZ抗原DTH反应暗示的催眠；（2）进行抑制DTH反应暗示的催眠；（3）仅进行放松暗示的催眠；（4）不进行催眠的皮肤测试。
一家教学医院中由美国国立卫生研究院支持的临床研究中心。
从门诊的、健康的、高催眠易感性的志愿者大学生中分层抽取24名，他们因在催眠暗示后具有高于平均水平的改变皮肤温度的能力以及对VZ抗原的阳性基线反应而被选中。其中有11名男性和13名女性，平均年龄±标准差为22±6岁。平均±标准差催眠易感性得分（哈佛群体催眠易感性量表）为11±1。
采用VZ抗原皮内皮肤测试（曼托试验法）和催眠暗示。
注射抗原后24小时和48小时测量的DTH反应硬结面积。
DTH反应面积不受实验干预的影响。红斑面积同样未受影响。
我们的受试者无法通过催眠暗示改变其DTH反应。
