Evans G, Grimwade D, Prentice H G, Simpson N
Department of Haematology, Addenbrookes Hospital, Cambridge.
Br J Haematol. 1997 Aug;98(2):437-9. doi: 10.1046/j.1365-2141.1997.2333050.x.
All-trans retinoic acid (ATRA) is currently recommended as standard treatment for acute promyelocytic leukaemia (APL). However, there has been increasing concern that ATRA is associated with unusual sites of relapse. We present three cases of APL previously treated with ATRA who ultimately relapsed within the central nervous system (CNS) and hypothesize that, by up-regulating intercellular adhesion molecules, ATRA may facilitate the passage of malignant promyelocytes across the blood-brain barrier.
全反式维甲酸（ATRA）目前被推荐作为急性早幼粒细胞白血病（APL）的标准治疗方法。然而，人们越来越担心ATRA与不寻常的复发部位有关。我们报告了3例先前接受过ATRA治疗的APL患者，这些患者最终在中枢神经系统（CNS）内复发，我们推测，通过上调细胞间粘附分子，ATRA可能会促进恶性早幼粒细胞穿过血脑屏障。
