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发育不良性雀斑样痣上的黑色素瘤

Melanoma on dysplastic nevus spilus.

作者信息

Grinspan D, Casala A, Abulafia J, Mascotto J, Allevato M

机构信息

Department of Dermatology, Hospital de Clínicas José de San Martin, University of Buenos Aires, Argentina.

出版信息

Int J Dermatol. 1997 Jul;36(7):499-502. doi: 10.1046/j.1365-4362.1997.00076.x.

Abstract

BACKGROUND

Nevus spilus is found with relative frequency. It is observed as as tan to brown macule serving as base to a speckle of smaller and darker maculo-papular elements. On rare occasions it turns into a malignant melanoma.

PURPOSES

To describe one case with some characteristics different from routine observations and to revise the cases published reporting nevus spilus that turned into malignant melanoma, in order to point out the most frequent aspects.

RESULTS

The 17 patients with nevus spilus and melanomas, including ours, were white, with ages between 35 and 56 years. Most of the cases were localized in the dorsal region. Five patients were men. Almost all nevus were congenital and their size ranged between 2 and 10 cm in diameter. Histologically, the speckled spots were junctional nevus, and few of them had dysplastic characteristics. Melanomas corresponded to the extensive superficial type MES; one of them was nodular. Some had systemic ganglial metastases and three of the patients are known to have died. Our patient had an intradermal cellular nevus on the man spot, and terminal hairs could be observed on it. The speckled elements were junctional nevus with dysplastic cells.

CONCLUSIONS

Nevus spilus must be closely monitored, because it may turn into a malignant melanoma.

摘要

背景

斑痣相对常见。表现为淡褐色至褐色斑疹,其上有较小且颜色较深的斑丘疹样斑点。极少数情况下,它会恶变为恶性黑色素瘤。

目的

描述一例具有一些与常规观察不同特征的病例,并对已发表的斑痣恶变为恶性黑色素瘤的病例进行回顾,以指出最常见的方面。

结果

包括我们的病例在内,17例斑痣合并黑色素瘤患者均为白人,年龄在35至56岁之间。大多数病例位于背部区域。5例为男性。几乎所有斑痣都是先天性的,直径在2至10厘米之间。组织学上,斑点状病变为交界痣,其中少数具有发育异常特征。黑色素瘤为广泛的浅表型MES;其中1例为结节型。部分患者有系统性淋巴结转移,已知3例患者死亡。我们的患者在斑疹部位有一个皮内细胞痣,其上可见终毛。斑点状病变为具有发育异常细胞的交界痣。

结论

斑痣必须密切监测,因为它可能恶变为恶性黑色素瘤。

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