Otsubo H, Yokoe H, Miya T, Atsuta F, Miura N, Tanzawa H, Sato K
Department of Oral Surgery, School of Medicine, Chiba University.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Aug;84(2):171-4. doi: 10.1016/s1079-2104(97)90065-2.
This article describes a gingival squamous cell carcinoma that developed in a 21-year-old woman who received a bone marrow transplant at the age of 16 from her human leukocyte antigen-identical sister as treatment for severe aplastic anemia. Thirty days after transplantation, she presented with cutaneous erythema as a result of acute graft-versus-host disease, and this subsequently evolved into chronic graft-versus-host disease. A lichenoid white plaque of the gingiva developed shortly thereafter, and it began to increase in size rapidly 4 years posttransplantation. Biopsy indicated squamous cell carcinoma arising in this region, apparently associated with chronic graft-versus-host disease. Few reports have described a secondary solid malignancy involving the oral cavity of young adults after bone marrow transplantation.
本文描述了一名21岁女性发生的牙龈鳞状细胞癌。该女性16岁时因严重再生障碍性贫血接受了来自其人类白细胞抗原匹配的姐姐的骨髓移植。移植后30天，她因急性移植物抗宿主病出现皮肤红斑，随后发展为慢性移植物抗宿主病。此后不久牙龈出现苔藓样白色斑块，移植后4年斑块大小开始迅速增大。活检显示该区域发生鳞状细胞癌，显然与慢性移植物抗宿主病有关。很少有报道描述骨髓移植后年轻成年人口腔出现继发性实体恶性肿瘤的情况。
