Danker-Hopfe H, Kuchheuser W
Department of Human Biology, University of Bremen.
Z Morphol Anthropol. 1995 Dec;81(1):3-21.
Serum specimens from 1385 unrelated males and females from seven Middle East and East European sample surveys (Prague, Olomouc, Krakow, Poznan, Szeged, Moscow, and Jekaterinburg) have been typed for seven polymorphic serum protein polymorphisms (GC, TF, PLG, PI, A2HS, F13B, and ITI). The distributions of phenotype and allele frequencies show a marked heterogeneity, especially with regard to the allel GC1F of the GC system, the alleles A2HS1 and A2HS2 of the A2HS system and the alleles F13B1 and F13B*3 allele of the F13B system. Analysis of the genetic variability by means of distance and principal component analysis revealed that with regard to the seven polymorphic loci studied the population samples from Prague and Jekaterinburg are characterized by deviating genetic structures. While the different genetic structure of the sample from Prague is mainly due to the distribution of the alleles at the A2HS locus, the sample from Jekaterinburg shows differences in several loci. The genetic dissimilarity corresponds to the large geographic distance from the other populations and can presumably be explained with the comparatively heterogeneous ethnic composition of the population of this city located at the geographic borderline between Europe and Asia.
对来自中东和东欧七个样本调查（布拉格、奥洛穆茨、克拉科夫、波兹南、塞格德、莫斯科和叶卡捷琳堡）的1385名无亲缘关系的男性和女性的血清样本进行了七种多态性血清蛋白多态性（GC、TF、PLG、PI、A2HS、F13B和ITI）分型。表型和等位基因频率分布显示出明显的异质性，特别是在GC系统的等位基因GC1F、A2HS系统的等位基因A2HS1和A2HS2以及F13B系统的等位基因F13B1和F13B*3方面。通过距离分析和主成分分析对遗传变异性进行分析后发现，就所研究的七个多态位点而言，来自布拉格和叶卡捷琳堡的人群样本具有偏离的遗传结构。虽然来自布拉格的样本的不同遗传结构主要归因于A2HS位点等位基因的分布，但来自叶卡捷琳堡的样本在几个位点上存在差异。这种遗传差异与该样本与其他人群的巨大地理距离相对应，并且大概可以用位于欧洲和亚洲地理边界的这座城市的人群相对异质的种族构成来解释。
