Catala M
Service d'Histologie, Embryologie et Cytogénétique/URA CNRS 2115, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Childs Nerv Syst. 1997 Jun;13(6):336-40. doi: 10.1007/s003810050092.
Spina bifida with lipoma is a human malformation that most often affects the lumbosacral area. It is a complex morphological type. Its origin is controversial, and none of the previous hypotheses can be retained in view of the most recent advances in experimental embryogenesis. Contrary to earlier opinions, adipocytes cannot arise from meninges, vessels or glial cells and spina bifida cannot be explained by incarceration of mesodermal tissues during primary neurulation or developmental defect at the level of the tail bud. Spina bifida with lipoma, which actually involves all the derivatives of the so-called dorsal mesoderm, must therefore result from abnormal development of this mesoderm, which is induced by the dorsal neural tube. The location of the primary defect (dorsal mesoderm or neural tube) remains to be established.
伴脂肪瘤的脊柱裂是一种最常累及腰骶部的人类畸形。它是一种复杂的形态学类型。其起源存在争议，鉴于实验胚胎发生学的最新进展，之前的假说均无法成立。与早期观点相反，脂肪细胞并非源自脑膜、血管或神经胶质细胞，脊柱裂也不能用原肠胚形成过程中中胚层组织的嵌顿或尾芽水平的发育缺陷来解释。因此，伴脂肪瘤的脊柱裂实际上累及了所谓背侧中胚层的所有衍生物，必定是由背侧神经管诱导的该中胚层异常发育所致。原发性缺陷（背侧中胚层或神经管）的位置仍有待确定。
