人类巨细胞病毒感染与系统性红斑狼疮

Human cytomegalovirus infection and systemic lupus erythematosus.

作者信息

Rider J R, Ollier W E, Lock R J, Brookes S T, Pamphilon D H

机构信息

National Blood Service, Bristol Centre, UK.

出版信息

Clin Exp Rheumatol. 1997 Jul-Aug;15(4):405-9.

PMID:9272302

Abstract

OBJECTIVE

Viruses are considered possible aetiologic agents of autoimmune disease. Evidence suggests that human cytomegalovirus (HCMV) may be a pathogenetic factor in systemic lupus erythematosus (SLE). We undertook a seroepidemiological study to determine whether HCMV infection is increased in patients with SLE.

METHODS

Sero-epidemiologic data, indicative of virus prevalence, were obtained by enzyme immunoassay.

RESULTS

Eighty-eight of 97 serum samples (90.7%) taken from adult patients with SLE were seropositive for HCMV. By contrast, HCMV was detected in only 32 of 50 (64.0%) adult patients with rheumatoid arthritis (RA) and 42 of 97 (43.3%) normal controls. The odds ratio for HCMV prevalence in SLE/normal controls was 14.53 (95% CI is 6.39 to 33.04). For comparison, data for herpes simplex virus-I (HSV-I) seropositivity were obtained from the same three groups. Seventy-eight patients with SLE (80.4%), 40 patients with RA (80.0%) and 57 normal controls (58.8%) were seropositive for this closely-related herpesvirus.

CONCLUSION

The data shows a specific and highly significant association between infection with HCMV and a clinical diagnosis of SLE.

摘要

目的

病毒被认为是自身免疫性疾病可能的病因。有证据表明，人类巨细胞病毒（HCMV）可能是系统性红斑狼疮（SLE）的致病因素。我们进行了一项血清流行病学研究，以确定SLE患者中HCMV感染率是否升高。

方法

通过酶免疫测定获得指示病毒流行率的血清流行病学数据。

结果

从成年SLE患者采集的97份血清样本中，88份（90.7%）HCMV血清学呈阳性。相比之下，在50名成年类风湿关节炎（RA）患者中，只有32份（64.0%）检测到HCMV，在97名正常对照者中，42份（43.3%）检测到HCMV。SLE患者与正常对照者中HCMV流行率的比值比为14.53（95%可信区间为6.39至33.04）。作为比较，从同一三组中获得了单纯疱疹病毒I型（HSV-I）血清学阳性的数据。78例SLE患者（80.4%）、40例RA患者（80.0%）和57名正常对照者（58.8%）对这种密切相关的疱疹病毒血清学呈阳性。