Althoff H
Med Klin. 1977 Nov 4;72(44):1871-9.
Eleven sudden deaths from coronary disease were studied in women aged 29--44 years. These cases occured between 1971 and 1976 in the Institute for Forensic Medicine, University of Cologne, BRD. Postmortal morphological examinations resulted excessive stenosed coronary arteries caused by arteriosclerosis in all cases, in eight combined with acute obstructing thrombus. Our study group is not representative of the incidence of fatal coronary disease in the community. The prevailing conclusions about influence of sex hormones from oral contraceptives upon the development of arteriosclerosis, hypercoagulability and thrombosis demonstrate contrary evaluation. Our reflections about aetiology and pathogenesis from the pathomorphological findings don't substantiate a proof correlation between coronary disease or coronary thrombosis and oral contraceptions. Many other factors are equal important. The opinion of increased incidence and risk for death from coronary disease in users of oral hormonal contraceptions is not evident for us.
对11例年龄在29至44岁之间死于冠心病的女性进行了研究。这些病例于1971年至1976年间发生在德意志联邦共和国科隆大学法医学研究所。尸检形态学检查结果显示,所有病例均存在由动脉硬化导致的冠状动脉过度狭窄,其中8例合并急性阻塞性血栓形成。我们的研究组并不代表社区中致命性冠心病的发病率。关于口服避孕药中的性激素对动脉硬化、高凝性和血栓形成发展的影响,目前流行的结论显示出相反的评价。我们从病理形态学发现对病因和发病机制的思考,并未证实冠心病或冠状动脉血栓形成与口服避孕药之间存在确凿关联。许多其他因素同样重要。对我们来说,口服激素避孕药使用者中冠心病发病率和死亡风险增加的观点并不明显。