Parkes I R, Zaki I, Stevens A, Davies J M, Allen B R
Department of Dermatology, University Hospital, Queen's Medical Centre, Nottingham, U.K.
Br J Dermatol. 1997 Jul;137(1):137-9.
Graft-versus-host disease (GVHD) is most commonly seen as a complication of bone marrow transplantation, although it can occur whenever tissue or blood products are given whereby immunologically competent donor lymphocytes react against host tissues. A 65-year-old man with non-Hodgkin's lymphoma developed a severe widespread erosive eruption of the skin and mucosal surfaces. Clinically and histologically it was identical to cutaneous GVHD even though the patient had never received tissue or blood products. He failed to respond to conventional therapy for GVHD, but his skin improved significantly on treating his underlying lymphoma, which eventually proved fatal. There are two previous reports of GVHD associated with malignancy but we believe this to be the first case secondary to a lymphoma.
移植物抗宿主病（GVHD）最常见于骨髓移植的并发症，不过只要给予组织或血液制品，免疫活性供体淋巴细胞对宿主组织产生反应时，它都可能发生。一名65岁的非霍奇金淋巴瘤男性患者出现了严重的、广泛的皮肤和黏膜表面糜烂性皮疹。临床和组织学表现与皮肤GVHD相同，尽管该患者从未接受过组织或血液制品。他对传统的GVHD治疗无反应，但在治疗其潜在的淋巴瘤后皮肤有显著改善，最终该淋巴瘤被证明是致命的。之前有两篇关于GVHD与恶性肿瘤相关的报道，但我们认为这是第一例继发于淋巴瘤的病例。
