一种38千道尔顿马尔尼菲青霉抗原与人免疫缺陷病毒阳性血清的免疫反应性。
Immunoreactivity of a 38-kilodalton Penicillium marneffei antigen with human immunodeficiency virus-positive sera.
作者信息
Chongtrakool P, Chaiyaroj S C, Vithayasai V, Trawatcharegon S, Teanpaisan R, Kalnawakul S, Sirisinha S
机构信息
Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
出版信息
J Clin Microbiol. 1997 Sep;35(9):2220-3. doi: 10.1128/jcm.35.9.2220-2223.1997.
Penicillium marneffei produced and secreted a 38-kDa antigen that appeared to be specific for this dimorphic fungus. This component could not be detected in antigenic extracts of Histoplasma capsulatum, Cryptococcus neoformans, Aspergillus niger, Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, Candida albicans, and two other species of Penicillium by immunoblot analysis against the sera from patients with culture-confirmed penicilliosis marneffei. Antibody reactive with this antigen was found in a large proportion of human immunodeficiency virus (HIV)-positive patients, indicating a presumptive diagnosis of P. marneffei infection. A small number of asymptomatic HIV-seropositive patients and HIV-seropositive patients with other fungal infections were also found to be positive by this analysis, suggesting that subclinical or mixed fungal infections involving P. marneffei are not uncommon.
马尔尼菲青霉菌产生并分泌一种38 kDa的抗原，该抗原似乎是这种双相真菌所特有的。通过对培养确诊的马尔尼菲青霉病患者血清进行免疫印迹分析，在荚膜组织胞浆菌、新型隐球菌、黑曲霉、烟曲霉、黄曲霉、土曲霉、白色念珠菌以及其他两种青霉菌的抗原提取物中均未检测到该成分。在大部分人类免疫缺陷病毒（HIV）阳性患者中发现了与该抗原反应的抗体，这表明可初步诊断为马尔尼菲青霉菌感染。通过该分析还发现，少数无症状的HIV血清阳性患者以及患有其他真菌感染的HIV血清阳性患者也呈阳性，这表明涉及马尔尼菲青霉菌的亚临床或混合真菌感染并不罕见。
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