Garlick R B, O'Brien M F
Department of Cardiac Surgery, Prince Charles Hospital, Brisbane, Australia.
Jpn Circ J. 1997 Aug;61(8):682-6. doi: 10.1253/jcj.61.682.
The CryoLife-O'Brien stentless valve is a composite trileaflet porcine aortic valve. It is assembled from 3 non-coronary leaflets and has no foreign material support. It is therefore truly stentless. From December 1992 to January 1996, 118 patients with aortic valve replacement had a CryoLife-O'Brien stentless valve inserted at the Prince Charles Hospital, Brisbane. The mean age was 73 years (range 59-89) and 54% were men. Most patients had aortic stenosis secondary to a calcific degenerative valve. Follow-up is 100% with hematological and echocardiographic studies before discharge, at 6 months, and at 12-18 months. Five deaths (2 early and 3 late) have occurred and morbidity includes 3 strokes, 1 peripheral embolism, 3 perivalvular leaks, and 1 patient with late endocarditis. Valve performance has been good, with low transvalvular gradients and only a trace or no regurgitation in over 95% of patients after 18 months. No structural deterioration or hemolysis has occurred. Echocardiographic surveillance confirms a very effective central orifice. Short-term results show that the overall performance of the CryoLife-O'Brien stentless valve has been very satisfactory, with low mortality and morbidity in this elderly group of patients. The benefits include the absence of prosthetic material, wide leaflet coaptation, and a quick and easy insertion. Long-term anticoagulation is not necessary. It is particularly suitable for elderly patients with a symmetrical aortic root.
CryoLife - O'Brien无支架瓣膜是一种复合三叶猪主动脉瓣。它由3个无冠状动脉瓣叶组装而成，没有异物支撑。因此它是真正的无支架瓣膜。1992年12月至1996年1月，118例接受主动脉瓣置换术的患者在布里斯班查尔斯王子医院植入了CryoLife - O'Brien无支架瓣膜。平均年龄为73岁（范围59 - 89岁），男性占54%。大多数患者患有继发于钙化性退行性瓣膜的主动脉瓣狭窄。出院前、6个月以及12 - 18个月时进行血液学和超声心动图研究，随访率达100%。已发生5例死亡（2例早期和3例晚期），发病情况包括3次中风、1次外周栓塞、3次瓣周漏以及1例晚期心内膜炎患者。瓣膜功能良好，跨瓣压差低，18个月后超过95%的患者仅有微量反流或无反流。未发生结构恶化或溶血。超声心动图监测证实中心孔非常有效。短期结果表明，CryoLife - O'Brien无支架瓣膜的总体性能非常令人满意，在这组老年患者中死亡率和发病率较低。其优点包括无人工材料、瓣叶贴合广泛、插入快速简便。无需长期抗凝。它特别适合主动脉根部对称的老年患者。
