Relaxation-induced EEG alterations in panic disorder patients.

Based on previous reports of relaxation-induced panic attacks in panic disorder patients, quantitative electroencephalographic (EEG) profiles and subjective anxiety ratings were assessed in panic disorder patients and normal controls listening to neutral and relaxation audiotapes. Regardless of tape condition, patients exhibited a greater frequency and severity of panic-related symptoms. Relaxation failed to alter panic-related symptom ratings or anxiety ratings in patients and controls. Theta and alpha increments were observed during relaxation, but only in normal controls. High frequency beta activity was less evident in patients, regardless of tape conditions. Results are discussed in relation to arousal and treatment issues in panic disorder.