成年早期的出生体重与认知功能：历史性队列研究
Birth weight and cognitive function in young adult life: historical cohort study.
作者信息
Sørensen H T, Sabroe S, Olsen J, Rothman K J, Gillman M W, Fischer P
机构信息
Department of Internal Medicine V, Aarhus University Hospital, Denmark.
出版信息
BMJ. 1997 Aug 16;315(7105):401-3. doi: 10.1136/bmj.315.7105.401.
OBJECTIVE
To examine the relation between birth weight and cognitive function in young adult life.
DESIGN
Retrospective cohort study based on birth registry data and cognitive function measured during evaluation for military service.
SUBJECTS
4300 Danish conscripts born between 1973 and 1975.
MAIN OUTCOME MEASURES
Mean score in the Boerge Prien test of cognitive function; score is the number of correct answers to 78 questions and correlates with full scale intelligence quotient (IQ).
RESULTS
Mean score in the Boerge Prien test increased from 39.9 at a birth weight of < or = 2500 g to 44.6 at a birth weight of 4200 g even after adjustment for gestational age and length at birth, maternal age and parity, and other variables. Above a birth weight of 4200 g the test score decreased slightly.
CONCLUSION
Birth weight is associated with cognitive performance in young adult life. Interference with fetal growth may influence adult cognitive performance.
目的
研究年轻成年期出生体重与认知功能之间的关系。
设计
基于出生登记数据和兵役评估期间测量的认知功能进行回顾性队列研究。
研究对象
4300名于1973年至1975年出生的丹麦应征入伍者。
主要观察指标
认知功能的伯格·普里恩测试中的平均得分；得分是对78个问题的正确答案数量，与全量表智商（IQ）相关。
结果
即使在对胎龄、出生身长、母亲年龄和产次以及其他变量进行校正后，伯格·普里恩测试的平均得分也从出生体重≤2500g时的39.9分增加到出生体重4200g时的44.6分。出生体重超过4200g时，测试得分略有下降。
结论
出生体重与年轻成年期的认知表现相关。对胎儿生长的干扰可能会影响成人的认知表现。
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