Boyle W, Kelso A, Leben M L
Nouv Rev Fr Hematol (1978). 1979;21(2):149-60.
Current concepts of the mechanism of alloactivation of cytotoxic lymphocytes and the identity of the target cell determinants with which they interact are reviewed. The results of a quantitative analysis of the stimulatory activity of different forms of antigen and the role of a costimulator factor are presented. These lead to the conclusions that SD antigens are not the target cell antigens and that existing theories of cytotoxic T cell activation are inadequate. A new theory of activation of alloareactive cytotoxic lymphocytes is proposed.
本文综述了细胞毒性淋巴细胞同种激活机制的当前概念以及它们相互作用的靶细胞决定簇的特性。文中还给出了不同形式抗原刺激活性的定量分析结果以及共刺激因子的作用。这些结果得出以下结论：SD抗原不是靶细胞抗原，现有的细胞毒性T细胞激活理论并不充分。本文提出了一种同种反应性细胞毒性淋巴细胞激活的新理论。
