Morris J A
Royal Lancaster Infirmary, UK.
Med Hypotheses. 1997 Aug;49(2):159-64. doi: 10.1016/s0306-9877(97)90221-8.
Concepts from information theory are used to develop a model in which genes control highly redundant systems. One consequence is that mutations interact synergistically and there will be selection against zygotes which have several mutations in any one system. This could explain why total mutational load in the human genome remains constant even though there are several new mutations per generation. This model has implications for fertility, polygenic disease and cancer. It also explains a fundamental biological problem concerning the advantage of sexual over asexual reproduction.
信息论中的概念被用于构建一个模型，在该模型中基因控制高度冗余的系统。一个结果是突变会协同相互作用，并且会对在任何一个系统中有多个突变的合子进行选择。这可以解释为什么即使每代有几个新突变，人类基因组中的总突变负荷仍保持恒定。该模型对生育力、多基因疾病和癌症具有启示意义。它还解释了一个关于有性生殖相对于无性生殖优势的基本生物学问题。
