Wick M R, Ritter J H, Humphrey P A, Nappi O
Department of Pathology, Washington University Medical Center, St Louis, Missouri 63110, USA.
Semin Diagn Pathol. 1997 Aug;14(3):183-202.
Clear cell tumors of the endocrine system and thymus are rare lesions with which surgical pathologists have only infrequent contact. As a result, these neoplasms may be misinterpreted and incorrectly classified. This review considers the histological, immunohistochemical, and ultrastructural features of clear cell pituitary adenomas, parathyroid tumors, pancreatic endocrine neoplasms, adrenocortical proliferations, and thymic malignancies. Emphasis is placed throughout on differential diagnosis with microscopically-similar lesions. Clear cell endocrine tumors and thymic lesions manifest a variety of potential lineages, including examples with epithelial, neural, germ cell, and lymphoid differentiation. Because of the wide differences in behavior and recommended treatment in this group, accuracy in diagnosis is essential.
内分泌系统和胸腺的透明细胞肿瘤是罕见病变，外科病理学家很少接触到。因此，这些肿瘤可能会被误诊和错误分类。本综述探讨了透明细胞垂体腺瘤、甲状旁腺肿瘤、胰腺内分泌肿瘤、肾上腺皮质增生及胸腺恶性肿瘤的组织学、免疫组化和超微结构特征。全文重点在于与显微镜下相似病变的鉴别诊断。透明细胞内分泌肿瘤和胸腺病变表现出多种潜在谱系，包括具有上皮、神经、生殖细胞和淋巴样分化的病例。由于该组病变在行为和推荐治疗方法上差异很大，准确诊断至关重要。
