幽门螺杆菌在巴雷特食管中的定植及其向癌症的进展。

Helicobacter pylori colonization of Barrett's esophagus and its progression to cancer.

作者信息

Wright T A, Myskow M, Kingsnorth A N

机构信息

Department of Surgery, Royal Liverpool Hospital, UK.

出版信息

Dis Esophagus. 1997 Jul;10(3):196-200. doi: 10.1093/dote/10.3.196.

DOI:10.1093/dote/10.3.196

PMID:9280079

Abstract

Helicobacter pylori (HP) plays a crucial role in gastric carcinogenesis. Few studies have looked at the relationship between HP and Barrett's esophagus/cancer. To further investigate this, a study comparing the prevalence of HP and increasing grades of dysplasia was undertaken. Biopsies from 19 malignant and 94 benign cases of Barrett's esophagus were analysed histologically for the presence of HP. 34% of non-dysplastic Barrett's epithelium was colonized with HP compared with only 17% of dysplastic/malignant cases (P = 0.04). No relationship was found between HP status and: (i) length of Barrett's esophagus; (ii) the presence of ulcers or strictures; and (iii) previous anti-reflux surgery. HP colonization of Barrett's esophagus is not uncommon. We found that HP has a negative correlation with increasing dysplasia which is analogous to gastric carcinogenesis. This finding should be investigated in prospective studies to elucidate its role in Barrett's adenocarcinoma.

摘要

幽门螺杆菌（HP）在胃癌发生过程中起着关键作用。很少有研究关注HP与巴雷特食管/癌症之间的关系。为了进一步研究这一问题，开展了一项比较HP患病率与发育异常程度增加之间关系的研究。对19例巴雷特食管恶性病例和94例良性病例的活检组织进行组织学分析，以检测HP的存在情况。34%的无发育异常的巴雷特上皮有HP定植，而发育异常/恶性病例中只有17%（P = 0.04）。未发现HP状态与以下因素之间存在关系：（i）巴雷特食管的长度；（ii）溃疡或狭窄的存在；（iii）既往抗反流手术史。巴雷特食管的HP定植并不罕见。我们发现HP与发育异常程度增加呈负相关，这与胃癌发生情况类似。这一发现应在前瞻性研究中进行调查，以阐明其在巴雷特腺癌中的作用。