Prysak M, Kisly A
Department of Obstetrics and Gynecology, St. John Hospital and Medical Center, Detroit, MI, USA.
J Perinatol. 1997 Jul-Aug;17(4):296-300.
To compare quantitative pregnancy risk of nulliparous women 35 years and older with nulliparous women 25 to 29 years old.
Maternal records for first births at three suburban hospitals from July 1, 1986, to June 30, 1990, were studied, risk-assessed retrospectively according to a group-specific risk-scoring system, and compared statistically according to age and quantitative pregnancy risk.
The older women were more likely to be high risk (score > or = 10) prepregnancy (odds ratio [OR] 2.9, 95% confidence interval [CI] 1.9 to 4.5), antepartum (OR 1.6, 95% CI 1.3 to 2.0), intrapartum (OR 2.2, 95% CI 1.8 to 2.6), and cumulatively (OR 2.6, 95% CI 2.2 to 3.2) when compared with younger women. They were also more likely to be very high risk (score > or = 20) antepartum (OR 1.8, 95% CI 1.1 to 2.9), intrapartum (OR 2.1, 95% CI 1.5 to 2.8), and cumulatively (OR 2.5, 95% CI 2.0 to 3.2). Risk increased progressively through pregnancy, revealing the intrapartum period as the time interval of maximum risk. Based on cumulative risk scoring, 64.9% of the older women were at least high risk, compared with 41.3% of the younger women (OR 2.6, 95% CI 2.2 to 3.2).
Nulliparous women 35 years and older from a predominantly middle-class, white population had a significantly higher quantifiable pregnancy risk than a similar group of women age 25 to 29, suggesting that age greater than 34 years is an independent pregnancy risk factor.
比较35岁及以上未生育女性与25至29岁未生育女性的定量妊娠风险。
对1986年7月1日至1990年6月30日期间三家郊区医院首次分娩的产妇记录进行研究，根据特定群体风险评分系统进行回顾性风险评估，并根据年龄和定量妊娠风险进行统计学比较。
与年轻女性相比，年龄较大的女性在孕前（优势比[OR]2.9，95%置信区间[CI]1.9至4.5）、产前（OR 1.6，95%CI 1.3至2.0）、产时（OR 2.2，95%CI 1.8至2.6）以及累积（OR 2.6，95%CI 2.2至3.2）时更有可能处于高风险（评分≥10）。她们在产前（OR 1.8，95%CI 1.1至2.9）、产时（OR 2.1，95%CI 1.5至2.8）以及累积（OR 2.5，95%CI 2.0至3.2）时也更有可能处于极高风险（评分≥20）。风险在整个孕期逐渐增加，表明产时是风险最高的时间段。基于累积风险评分，64.9%的年龄较大女性至少处于高风险，而年轻女性为41.3%（OR 2.6，95%CI 2.2至3.2）。
来自以中产阶级白人为主的人群中，35岁及以上的未生育女性的可量化妊娠风险显著高于年龄在25至29岁的类似女性群体，这表明年龄大于34岁是一个独立的妊娠风险因素。
