Nagao S, Kitazawa H, Osanai R, Hiramatsu T
Department of Physiology, Jichi Medical School, Tochigi, Japan.
Neurosci Lett. 1997 Aug 1;231(1):41-4. doi: 10.1016/s0304-3940(97)00518-1.
The acute effects of (6R)-5,6,7,8-tetrahydro-L-biopterin (R-THBP) on the dynamic characteristics of horizontal vestibulo-ocular reflex (HVOR) were examined in chronically prepared alert pigmented rabbits. The HVOR gain was measured by 10 degrees-0.1 Hz sinusoidal oscillation of the turntable in darkness. In control rabbits, intramuscular injection of R-THBP (10 mg/kg) induced an increase of HVOR gain by 0.1-0.2, which lasted for 1-3 h. Sustained 10 degrees-0.1 Hz sinusoidal oscillation of the turntable and screen in the reversed direction induced an adaptive increase of HVOR gain by 0.2 in 3 h, which was not affected by applications of R-THBP. In flocculus lesioned rabbits, the HVOR gain reduced by 23%, and applications of R-THBP no longer induced a HVOR gain increase. These experimental observations suggested that the R-THBP affected on the HVOR dynamics within the cerebellar flocculus or its related neural areas.
在长期制备的清醒有色家兔中，研究了(6R)-5,6,7,8-四氢-L-生物蝶呤（R-THBP）对水平前庭眼反射（HVOR）动态特性的急性影响。通过在黑暗中以10度-0.1赫兹的正弦振荡旋转转盘来测量HVOR增益。在对照家兔中，肌肉注射R-THBP（10毫克/千克）可使HVOR增益增加0.1-0.2，并持续1-3小时。转盘和屏幕以相反方向持续进行10度-0.1赫兹的正弦振荡，可在3小时内使HVOR增益适应性增加0.2，这不受R-THBP应用的影响。在小脑绒球损伤的家兔中，HVOR增益降低了23%，应用R-THBP不再引起HVOR增益增加。这些实验观察结果表明，R-THBP对小脑绒球或其相关神经区域内的HVOR动态有影响。
