Haig D M, McInnes C, Deane D, Reid H, Mercer A
The Moredun Research Institute, Edinburgh, UK.
Comp Immunol Microbiol Infect Dis. 1997 Jun;20(3):197-204. doi: 10.1016/s0147-9571(96)00045-8.
Orf virus is a zoonotic, epitheliotropic DNA parapox virus that principally infects sheep and goats. The fact that the virus can repeatedly reinfect sheep has provoked an interest in the underlying cellular, virological and molecular mechanisms for its apparent escape from the host protective immune response. The local immune and inflammatory response in skin and the cell phenotype and cytokine response in lymph analysed around a single lymph node are characteristic of an anti-viral response. An unusual feature is the dense accumulation of MHC Class II+ dendritic cells in the skin lesion. The function of these cells is not known. Orf virus virulence genes and activities have been identified that may interfere with the development of the host protective immune and inflammatory response.
羊痘病毒是一种人畜共患的嗜上皮性DNA副痘病毒，主要感染绵羊和山羊。该病毒能够反复感染绵羊，这一事实引发了人们对其明显逃避宿主保护性免疫反应背后的细胞、病毒学和分子机制的兴趣。皮肤中的局部免疫和炎症反应以及围绕单个淋巴结分析的淋巴结中的细胞表型和细胞因子反应是抗病毒反应的特征。一个不寻常的特征是皮肤病变中MHC II类+树突状细胞的密集聚集。这些细胞的功能尚不清楚。已经鉴定出可能干扰宿主保护性免疫和炎症反应发展的羊痘病毒毒力基因和活性。
